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• W332281330 abstract "Objective: We conducted the present meta-analysis to investigate whether single-nucleotide polymorphisms (SNPs) in the SUMO1 gene contribute to the risk of nonsyndromic cleft lip with or without palate (NSCL/P). Method: The Web of Science (1945–2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966–2013), EMBASE (1980–2013), CINAHL (1982–2013), and the Chinese Biomedical Database (CBM) (1982–2013) were searched without language restrictions. Meta-analysis was performed with the use of the STATA statistical software. Results: Six studies with a total of 1381 NSCL/P patients and 2054 control subjects were included. Twenty-seven functional polymorphisms in the SUMO1 gene were assessed. Our results indicated that SUMO1 genetic polymorphisms were correlated with an increased risk of NSCL/P. Subgroup analysis by the SNP type indicated that 4 functional polymorphisms (rs12470401 T>C, rs16838917 A>G, rs12470529 A>G, and rs7572505 A>G) in the SUMO1 gene might be strongly correlated with NSCL/P risk. Furthermore, ethnicity-stratified analysis demonstrated that SUMO1 genetic polymorphisms were closely related to an increased risk of NSCL/P among both Asians and Caucasians. Conclusion: Our findings provide empirical evidence that SUMO1 genetic polymorphisms might be strongly involved in the etiology of NSCL/P, especially for rs12470401 T>C, rs16838917 A>G, rs12470529 A>G, and rs7572505 A>G polymorphisms." @default.
• W332281330 created "2016-06-24" @default.
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• W332281330 date "2014-09-01" @default.
• W332281330 modified "2023-10-18" @default.
• W332281330 title "<i>SUMO1</i> Genetic Polymorphisms May Contribute to the Risk of Nonsyndromic Cleft Lip With or Without Palate: A Meta-Analysis" @default.
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• W332281330 doi "https://doi.org/10.1089/gtmb.2014.0056" @default.
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