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- W332328223 endingPage "248" @default.
- W332328223 startingPage "187" @default.
- W332328223 abstract "This chapter focuses on the cystic fibrosis (CF) transmembrane conductance regulator ( CFTR ) in the gastrointestinal (GI) system. CF commonly presents with pancreatic, intestinal, and hepatobiliary lesions. CFTR expression, function, and dysfunction in the GI system is reviewed anatomically throughout the GI system. Because a large body of information relevant to this subject is derived from nonhuman sources, including rodents and sharks, data from such sources also are included where applicable. The region of the GI system where the knowledge regarding the expression and/or function of CFTR remains incomplete is explored. The cloning and characterization of CFTR reveal it to be a member of a family of ATP-binding cassette (ABC) transporters that includes the multidrug resistance proteins (MDR-1, MRP), the sulfonylurea receptor (SUR), and STE-6 (yeast α-mating factor transporter). CFTR traffics to the apical membrane within trans-Golgi-derived secretory vesicles that are yet to be fully defined. The recycling of CFTR from the apical membrane occurs through clathrin-coated pits. Because CFTR resides for periods within cytoplasmic organelles and vesicles, it is possible that it also has a function at these sites." @default.
- W332328223 created "2016-06-24" @default.
- W332328223 creator A5046328580 @default.
- W332328223 creator A5046675325 @default.
- W332328223 date "2000-01-01" @default.
- W332328223 modified "2023-09-28" @default.
- W332328223 title "Chapter 6 The cystic fibrosis transmembrane conductance regulator in the gastrointestinal system" @default.
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