Matches in SemOpenAlex for { <https://semopenalex.org/work/W33253094> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W33253094 endingPage "8" @default.
- W33253094 startingPage "985" @default.
- W33253094 abstract "High-dose methotrexate (MTX) cytotoxicity is maintained in MCF-7 breast cancer cells but reduced in Hs824.T human bone marrow by a priming and nontoxic 5-fluorouracil (5-FU) dose. When MCF-7 breast or Hs824.T bone marrow cells are incubated with 10 microM 5-FU and 10 microM MTX for 48 h, the growth rates of breast cancer cells were 97.59 +/- 0.97% and 21.81 +/- 3.33% of the control rate, respectively, and the growth rates of bone marrow cells were 90.61 +/- 3.71% and 29.58 +/- 2.99% of the control rate. The combinations of 5-FU 2 h prior to MTX or MTX 2 h prior to 5-FU followed by a 48 h incubation, respectively, gave growth rates of 20.96 +/- 2.44% and 19.86 +/- 2.56% of the control rate for MCF-7 cells. In bone marrow cells, the combinations of 5-FU 2 h prior to MTX or MTX 2 h prior to 5-FU followed by a 48 h incubation, respectively, gave growth rates of 79.66 +/- 7.41% (protection) and 31.39 +/- 1.77% of the control rate. Similar patterns to bone marrow emerges in platelets. These studies suggest that: a) MTX and 5-FU combination on the growth of human MCF-7 breast cancer cells is independent of sequence; and b) a priming-dose of 5-FU will protect bone marrow from MTX cytotoxicity but not breast cancer cells. Therefore, a priming and non-toxic dose of 5-FU and MTX may have maximum antineoplastic activity while at the same time provide protection to the hematopoietic system." @default.
- W33253094 created "2016-06-24" @default.
- W33253094 creator A5005062950 @default.
- W33253094 creator A5023081058 @default.
- W33253094 creator A5046176824 @default.
- W33253094 creator A5047049767 @default.
- W33253094 creator A5066793774 @default.
- W33253094 date "1999-06-16" @default.
- W33253094 modified "2023-09-23" @default.
- W33253094 title "5-Fluorouracil simultaneously maintains methotrexate antineoplastic activity in human breast cancer and protects against methotrexate cytotoxicity in human bone marrow." @default.
- W33253094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10368642" @default.
- W33253094 hasPublicationYear "1999" @default.
- W33253094 type Work @default.
- W33253094 sameAs 33253094 @default.
- W33253094 citedByCount "4" @default.
- W33253094 crossrefType "journal-article" @default.
- W33253094 hasAuthorship W33253094A5005062950 @default.
- W33253094 hasAuthorship W33253094A5023081058 @default.
- W33253094 hasAuthorship W33253094A5046176824 @default.
- W33253094 hasAuthorship W33253094A5047049767 @default.
- W33253094 hasAuthorship W33253094A5066793774 @default.
- W33253094 hasConcept C100701293 @default.
- W33253094 hasConcept C109316439 @default.
- W33253094 hasConcept C121608353 @default.
- W33253094 hasConcept C126322002 @default.
- W33253094 hasConcept C202751555 @default.
- W33253094 hasConcept C203014093 @default.
- W33253094 hasConcept C2776694085 @default.
- W33253094 hasConcept C2776755627 @default.
- W33253094 hasConcept C2779707156 @default.
- W33253094 hasConcept C2780007613 @default.
- W33253094 hasConcept C2780456651 @default.
- W33253094 hasConcept C2781059491 @default.
- W33253094 hasConcept C502942594 @default.
- W33253094 hasConcept C530470458 @default.
- W33253094 hasConcept C55493867 @default.
- W33253094 hasConcept C59822182 @default.
- W33253094 hasConcept C71924100 @default.
- W33253094 hasConcept C81444415 @default.
- W33253094 hasConcept C86803240 @default.
- W33253094 hasConcept C98274493 @default.
- W33253094 hasConceptScore W33253094C100701293 @default.
- W33253094 hasConceptScore W33253094C109316439 @default.
- W33253094 hasConceptScore W33253094C121608353 @default.
- W33253094 hasConceptScore W33253094C126322002 @default.
- W33253094 hasConceptScore W33253094C202751555 @default.
- W33253094 hasConceptScore W33253094C203014093 @default.
- W33253094 hasConceptScore W33253094C2776694085 @default.
- W33253094 hasConceptScore W33253094C2776755627 @default.
- W33253094 hasConceptScore W33253094C2779707156 @default.
- W33253094 hasConceptScore W33253094C2780007613 @default.
- W33253094 hasConceptScore W33253094C2780456651 @default.
- W33253094 hasConceptScore W33253094C2781059491 @default.
- W33253094 hasConceptScore W33253094C502942594 @default.
- W33253094 hasConceptScore W33253094C530470458 @default.
- W33253094 hasConceptScore W33253094C55493867 @default.
- W33253094 hasConceptScore W33253094C59822182 @default.
- W33253094 hasConceptScore W33253094C71924100 @default.
- W33253094 hasConceptScore W33253094C81444415 @default.
- W33253094 hasConceptScore W33253094C86803240 @default.
- W33253094 hasConceptScore W33253094C98274493 @default.
- W33253094 hasIssue "2A" @default.
- W33253094 hasLocation W332530941 @default.
- W33253094 hasOpenAccess W33253094 @default.
- W33253094 hasPrimaryLocation W332530941 @default.
- W33253094 hasRelatedWork W111599678 @default.
- W33253094 hasRelatedWork W1524793778 @default.
- W33253094 hasRelatedWork W2014203514 @default.
- W33253094 hasRelatedWork W2020397817 @default.
- W33253094 hasRelatedWork W2037336128 @default.
- W33253094 hasRelatedWork W2043571308 @default.
- W33253094 hasRelatedWork W2400065763 @default.
- W33253094 hasRelatedWork W2407213037 @default.
- W33253094 hasRelatedWork W2416825661 @default.
- W33253094 hasRelatedWork W33253094 @default.
- W33253094 hasVolume "19" @default.
- W33253094 isParatext "false" @default.
- W33253094 isRetracted "false" @default.
- W33253094 magId "33253094" @default.
- W33253094 workType "article" @default.