Matches in SemOpenAlex for { <https://semopenalex.org/work/W33291310> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W33291310 endingPage "15" @default.
- W33291310 startingPage "8" @default.
- W33291310 abstract "The bioavailability of seocalcitol from two lipid-based formulations and a propylene glycol (PG) solution was studied in minipigs in the fasted and fed state. The lipid-based formulations were a medium chain triglyceride (MCT) solution and a self-microemulsifying drug delivery system (MC-SMEDDS) having a composition of 25% MCT, 48% cremophor RH 40, 27% akoline MCM. An IV solution was administered in order to determine the absolute bioavailability. In the fasted state the absolute bioavailability of seocalcitol was 15, 21 and 28% for the PG, MCT and MC-SMEDDS, respectively. The bioavailability from the PG solution was affected by the presence of food (29%), whereas the bioavailability from the lipid-based formulations was less affected by the presence of food; MCT (22%) and MC-SMEDDS (33%). The increased bioavailability from the PG solution in the fed state is believed to be due to the presence of lipids in the food. The present study illustrates an often mentioned beneficial effect of dosing lipid-based formulations; the reduced food effect on bioavailability. Previously published solubility data in simulated intestinal media relates very well to the present in vivo findings as the solubility studies showed that addition of lipids to the formulation could reduce/eliminate the difference in solubility between the fasted and fed state. Previously the same formulations were dosed to rats, resulting in a lower bioavailability from the MC-SMEDDS compared to the MCT. This illustrates that the animal model used should be carefully considered when studying formulations that are dependent on the dynamic processes in the GIT." @default.
- W33291310 created "2016-06-24" @default.
- W33291310 creator A5007404497 @default.
- W33291310 creator A5044979505 @default.
- W33291310 creator A5064072022 @default.
- W33291310 creator A5087056267 @default.
- W33291310 date "2007-05-01" @default.
- W33291310 modified "2023-09-26" @default.
- W33291310 title "Bioavailability of seocalcitol" @default.
- W33291310 cites W141593724 @default.
- W33291310 cites W1498305210 @default.
- W33291310 cites W176348932 @default.
- W33291310 cites W1963962723 @default.
- W33291310 cites W1977473496 @default.
- W33291310 cites W1990432963 @default.
- W33291310 cites W1998489077 @default.
- W33291310 cites W2003026126 @default.
- W33291310 cites W2003349100 @default.
- W33291310 cites W2018445772 @default.
- W33291310 cites W2034615747 @default.
- W33291310 cites W2035603089 @default.
- W33291310 cites W2041016731 @default.
- W33291310 cites W2048883334 @default.
- W33291310 cites W2060992818 @default.
- W33291310 cites W2080670633 @default.
- W33291310 cites W2098273417 @default.
- W33291310 cites W2123187284 @default.
- W33291310 cites W2132534186 @default.
- W33291310 cites W2156285632 @default.
- W33291310 cites W261061428 @default.
- W33291310 cites W282644434 @default.
- W33291310 cites W63350312 @default.
- W33291310 doi "https://doi.org/10.1016/j.ejps.2007.01.007" @default.
- W33291310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17383165" @default.
- W33291310 hasPublicationYear "2007" @default.
- W33291310 type Work @default.
- W33291310 sameAs 33291310 @default.
- W33291310 citedByCount "35" @default.
- W33291310 countsByYear W332913102012 @default.
- W33291310 countsByYear W332913102013 @default.
- W33291310 countsByYear W332913102014 @default.
- W33291310 countsByYear W332913102015 @default.
- W33291310 countsByYear W332913102016 @default.
- W33291310 countsByYear W332913102017 @default.
- W33291310 countsByYear W332913102018 @default.
- W33291310 countsByYear W332913102019 @default.
- W33291310 countsByYear W332913102020 @default.
- W33291310 countsByYear W332913102022 @default.
- W33291310 countsByYear W332913102023 @default.
- W33291310 crossrefType "journal-article" @default.
- W33291310 hasAuthorship W33291310A5007404497 @default.
- W33291310 hasAuthorship W33291310A5044979505 @default.
- W33291310 hasAuthorship W33291310A5064072022 @default.
- W33291310 hasAuthorship W33291310A5087056267 @default.
- W33291310 hasConcept C155574463 @default.
- W33291310 hasConcept C178790620 @default.
- W33291310 hasConcept C181389837 @default.
- W33291310 hasConcept C185592680 @default.
- W33291310 hasConcept C2778163477 @default.
- W33291310 hasConcept C2778913445 @default.
- W33291310 hasConcept C31903555 @default.
- W33291310 hasConcept C43617362 @default.
- W33291310 hasConcept C55493867 @default.
- W33291310 hasConcept C71924100 @default.
- W33291310 hasConcept C98274493 @default.
- W33291310 hasConceptScore W33291310C155574463 @default.
- W33291310 hasConceptScore W33291310C178790620 @default.
- W33291310 hasConceptScore W33291310C181389837 @default.
- W33291310 hasConceptScore W33291310C185592680 @default.
- W33291310 hasConceptScore W33291310C2778163477 @default.
- W33291310 hasConceptScore W33291310C2778913445 @default.
- W33291310 hasConceptScore W33291310C31903555 @default.
- W33291310 hasConceptScore W33291310C43617362 @default.
- W33291310 hasConceptScore W33291310C55493867 @default.
- W33291310 hasConceptScore W33291310C71924100 @default.
- W33291310 hasConceptScore W33291310C98274493 @default.
- W33291310 hasIssue "1" @default.
- W33291310 hasLocation W332913101 @default.
- W33291310 hasLocation W332913102 @default.
- W33291310 hasOpenAccess W33291310 @default.
- W33291310 hasPrimaryLocation W332913101 @default.
- W33291310 hasRelatedWork W1842011178 @default.
- W33291310 hasRelatedWork W1985335458 @default.
- W33291310 hasRelatedWork W2035603089 @default.
- W33291310 hasRelatedWork W2899220175 @default.
- W33291310 hasRelatedWork W2905459561 @default.
- W33291310 hasRelatedWork W2910597072 @default.
- W33291310 hasRelatedWork W2961856113 @default.
- W33291310 hasRelatedWork W3024294278 @default.
- W33291310 hasRelatedWork W3133565818 @default.
- W33291310 hasRelatedWork W875949149 @default.
- W33291310 hasVolume "31" @default.
- W33291310 isParatext "false" @default.
- W33291310 isRetracted "false" @default.
- W33291310 magId "33291310" @default.
- W33291310 workType "article" @default.