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- W33331110 abstract "Structural brain phenotypes are quantitative traits showing considerable variation in human populations. Quantitative structural brain abnormalities are also repeatedly reported in patients with psychiatric disorders such as schizophrenia. Studying the genetic and environmental causes of these differences might therefore highlight biological mechanisms underlying neuroanatomical phenotypes and directly result in the identification of risk factors for schizophrenia. Heritability estimates indicate a strong genetic component contributing to neuroanatomical phenotypes. Brain structure volumes have substantial heritability rates ranging from high (70-95%) for total brain volume, cerebellar, gray and white matter, and corpus callosum, to moderate (40-70%) determined for the hippocampus, the four lobes (frontal, temporal, occipital, and parietal lobe), temporal horn volume, brain parenchyma, white matter hyperintensity, and planum temporal asymmetry. Middle structures of the brain show high heritability scores for the deeper structures (ontogenetically earlier formed) and moderate heritability scores for the surface structures. Structures formed earlier in development show consistently higher heritability rates than brain structures formed later in development, for example, surface structures, which seem to be influenced by environmental factors. Even higher heritability reaching 0.99 for total brain volume are estimated in nonhuman primate (NHP) models employing inbred extended pedigree and highly uniform rearing conditions, reducing the effects of environmental factors. Applying highly heritable structural brain phenotypes may serve as an endophenotype for gene mapping studies and lead to identification of genes that are involved in the regulation of human brain volume and the biological mechanisms involved in the causal mechanisms of psychiatric disorders." @default.
- W33331110 created "2016-06-24" @default.
- W33331110 creator A5024796415 @default.
- W33331110 creator A5051831220 @default.
- W33331110 date "2009-01-01" @default.
- W33331110 modified "2023-10-10" @default.
- W33331110 title "Heritability of Structural Brain Traits" @default.
- W33331110 cites W1531539933 @default.
- W33331110 cites W1536700299 @default.
- W33331110 cites W1550462067 @default.
- W33331110 cites W1570921843 @default.
- W33331110 cites W1603278492 @default.
- W33331110 cites W1628245979 @default.
- W33331110 cites W1963673462 @default.
- W33331110 cites W1964118164 @default.
- W33331110 cites W1967526316 @default.
- W33331110 cites W1968589454 @default.
- W33331110 cites W1969768666 @default.
- W33331110 cites W1971316923 @default.
- W33331110 cites W1971744121 @default.
- W33331110 cites W1971887764 @default.
- W33331110 cites W1972205948 @default.
- W33331110 cites W1972429997 @default.
- W33331110 cites W1973246758 @default.
- W33331110 cites W1974059537 @default.
- W33331110 cites W1975310564 @default.
- W33331110 cites W1976408965 @default.
- W33331110 cites W1976754871 @default.
- W33331110 cites W1977791488 @default.
- W33331110 cites W1978489134 @default.
- W33331110 cites W1979353798 @default.
- W33331110 cites W1979832807 @default.
- W33331110 cites W1980386941 @default.
- W33331110 cites W1980719669 @default.
- W33331110 cites W1981968256 @default.
- W33331110 cites W1984559620 @default.
- W33331110 cites W1984997727 @default.
- W33331110 cites W1985671693 @default.
- W33331110 cites W1987305498 @default.
- W33331110 cites W1991965466 @default.
- W33331110 cites W1993340420 @default.
- W33331110 cites W1994137501 @default.
- W33331110 cites W1995511716 @default.
- W33331110 cites W1996274075 @default.
- W33331110 cites W1997038056 @default.
- W33331110 cites W1997344968 @default.
- W33331110 cites W2001482790 @default.
- W33331110 cites W2001815232 @default.
- W33331110 cites W2003268155 @default.
- W33331110 cites W2003759197 @default.
- W33331110 cites W2005558551 @default.
- W33331110 cites W2010993988 @default.
- W33331110 cites W2011475205 @default.
- W33331110 cites W2012731551 @default.
- W33331110 cites W2013373204 @default.
- W33331110 cites W2016122118 @default.
- W33331110 cites W2016558382 @default.
- W33331110 cites W2016997563 @default.
- W33331110 cites W2017090646 @default.
- W33331110 cites W2018384285 @default.
- W33331110 cites W2019331300 @default.
- W33331110 cites W2020897240 @default.
- W33331110 cites W2026892549 @default.
- W33331110 cites W2030532121 @default.
- W33331110 cites W2030916472 @default.
- W33331110 cites W2031106541 @default.
- W33331110 cites W2031597554 @default.
- W33331110 cites W2032147029 @default.
- W33331110 cites W2033336411 @default.
- W33331110 cites W2034892899 @default.
- W33331110 cites W2034916586 @default.
- W33331110 cites W2035964780 @default.
- W33331110 cites W2037212221 @default.
- W33331110 cites W2041104744 @default.
- W33331110 cites W2041234594 @default.
- W33331110 cites W2041576587 @default.
- W33331110 cites W2042513568 @default.
- W33331110 cites W2046141452 @default.
- W33331110 cites W2046942679 @default.
- W33331110 cites W2049409353 @default.
- W33331110 cites W2049473772 @default.
- W33331110 cites W2056050981 @default.
- W33331110 cites W2057658065 @default.
- W33331110 cites W2057680708 @default.
- W33331110 cites W2059631901 @default.
- W33331110 cites W2061196406 @default.
- W33331110 cites W2061730652 @default.
- W33331110 cites W2066143011 @default.
- W33331110 cites W2068367820 @default.
- W33331110 cites W2069922847 @default.
- W33331110 cites W2073338480 @default.
- W33331110 cites W2077630079 @default.
- W33331110 cites W2080086149 @default.
- W33331110 cites W2080822231 @default.
- W33331110 cites W2083339079 @default.
- W33331110 cites W2084154495 @default.
- W33331110 cites W2085813069 @default.
- W33331110 cites W2092516228 @default.