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- W333426532 abstract "Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors. They belong to a 7-member family of intracellular factors that mediate actions of a variety of peptide hormones and cytokines within target cells. In this study, the T→C nucleotide polymorphism at position 12743 in exon 16 of the bovine STAT5A gene was investigated with PCR-RFLP in a sample of thirty-five cattle belonging to Podolica breed. Genetic sequence of exon 16 is responsible for encoding the transactivation domain SH2 of the bovine STAT5A factor. The T→C transition at position 12743 changes the amino acid sequence in the STAT5A protein and it has already been shown to modify the STAT5A DNA-binding properties. The Podolica breed derives from Bos primigenius podolicus (forebears of the modern Bos taurus), it has been present in Italy for a very long time and represents yet another example of successful biological adaptation to a hostile environment. The aim of this study was to estimate the allele and genotype frequencies in the sample of Podolica cattle. The possible deviations of genotypic frequencies from expectation under Hardy-Weinberg equilibrium, were tested by a Chi-square test. Moreover some population genetic indexes (gene heterozygosity, gene homozygosity, effective allele numbers, fixation index and polymorphism information content were calculated. All the three possible genotypes for the considered polymorphism were identified. The observed frequencies of C and T alleles were 0.34 and 0.66 respectively. The TT genotype was the most frequent in the studied population (45.71%) followed by TC genotype (40.00%) and CC genotype (14.29%)." @default.
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- W333426532 date "2012-01-01" @default.
- W333426532 modified "2023-09-27" @default.
- W333426532 title "Analysis of a sequence nucleotide polymorphism in exon 16 of the STAT5A gene in Podolica cattle breed." @default.
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