Matches in SemOpenAlex for { <https://semopenalex.org/work/W33363750> ?p ?o ?g. }
- W33363750 endingPage "225" @default.
- W33363750 startingPage "195" @default.
- W33363750 abstract "Experiments in animals and humans over the past 20 years have demonstrated that autoreactive CD4+ T cells are normal constituents of the T cell repertoire in healthy individuals. A diverse range of laboratory animals mount autoimmune responses following immunization with self proteins, such as Type II collagen and myelin proteins, the presumed (MBP) (1, 2, 3, 4, 5). Furthermore, autoantigen-specific CD4+ T cells are routinely detected among peripheral blood lymphocytes collected from healthy human volunteers. For example, in a number of studies T cell lines specific for myelin proteins, the presumed autoantigens targeted in multiple sclerosis (MS), have been propagated from blood samples obtained from asymptomatic controls (6, 7, 8, 9, 10, 11, 12, 13, 14). Surprisingly, several investigators have found the precursor frequency of myelin-specific T cells to be comparable between healthy individuals and MS patients (9, 10, 11, 12, 13, 14). Collectively, these observations suggest that a significant number of autoreactive T cells ordinarily escape both negative selection in the thymus and clonal deletion in the periphery, and that their survival in the peripheral pool of mature T cells is not, in and of itself, predictive of autoimmune disease." @default.
- W33363750 created "2016-06-24" @default.
- W33363750 creator A5005119540 @default.
- W33363750 creator A5039903543 @default.
- W33363750 date "2002-01-01" @default.
- W33363750 modified "2023-09-23" @default.
- W33363750 title "Cytokines and Resistance to Organ Specific Autoimmune Disease" @default.
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