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- W33370549 abstract "The concentrations of various steroids of adrenal origin were assessed in vivo before and after acute adrenocorticotropic hormone (ACTH) stimulation to determine the effects of danazol on adrenal steroidogenesis. Five healthy, normal menstruating women were studied on the 6th day of two consecutive menstrual cycles, once as a pretreatment control and again after administration of 600 mg of danazol daily for 6 days. While taking danazol, baseline levels of progesterone (P) (P < 0.01), dehydroepiandrosterone (DHEA) (P < 0.05), and androstenedione (∆4A) (P < 0.05) were elevated, whereas baseline levels of luteinizing hormone, follicle-stimulating hormone, and ACTH were not significantly changed. Danazol levels were 383.8 ± 58 (SEM) ng/ml after the period of administration. As compared with pre-danazol control values, the response to ACTH after danazol administration was greater for pregnenolone (∆5P) (P < 0.005) and 11-deoxycortisol (S) (P < 0.05) and smaller for progesterone (P) (P < 0.01) and cortisol (F) (P > 0.05). Consequently, the ∆5P:P (P < 0. 005) and S:F (P < 0.05) ratios were increased. These results are consistent with, and support in vitro data for, the inhibition by danazol of adrenal 3β-ol-hydroxysteroid dehydrogenase ∆5-∆4 isomerase and 11β-hydroxylase enzymes." @default.
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- W33370549 date "1980-04-01" @default.
- W33370549 modified "2023-09-27" @default.
- W33370549 title "Inhibition of Adrenal Steroidogenesis by Danazol in Vivo" @default.
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- W33370549 doi "https://doi.org/10.1016/s0015-0282(16)44657-1" @default.
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