FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W334090985> ?p ?o ?g. }

• W334090985 abstract "The investigators of the COMBINE (Combining Medications and Behavioral Interventions for Alcoholism) Study aimed to determine whether naltrexone, a drug alleged to reduce cravings for alcohol, combined with a behavioral intervention (CBI) assumed to change stress and coping behaviors, improves drinking outcomes more than either alone. After 16 weeks, only naltrexone alone and CBI alone significantly increased percent days abstinent (PDA) in models controlling for baseline PDA and site of treatment administration. Unexpectedly, the naltrexone + CBI combination did not offer any advantage over either naltrexone alone or CBI alone. To understand moderating and mediating factors, and to help explain the Combination's lack of improvement over each monotherapy, controlled and natural direct effect analyses were performed using targeted maximum likelihood estimation (TMLE). TMLE offers several advantages over traditional direct effect analytic approaches such as double-robustness and allowance of treatment moderation by potential mediators. Cravings and stress were examined as theoretically informed mediators/moderators. Controlled direct effect results show that naltrexone, CBI, and the Combination all work best when cravings are high, while none work when cravings are low. Similarly, naltrexone and the Combination work better when stress is high. Natural direct/indirect effect results show that all three treatments' effects are at least partially mediated by cravings, and that craving reduction explains 47-63% of treatment effects. Furthermore, naltrexone appears to affect cravings earlier while CBI works later. Taken together, the set of results suggests the possibility of a threshold effect; if naltrexone reduces cravings early on and CBI is not effective when cravings are low, then the Combination's lack of improvement over either monotherapy should not be surprising." @default.
• W334090985 created "2016-06-24" @default.
• W334090985 creator A5023702385 @default.
• W334090985 date "2012-01-01" @default.
• W334090985 modified "2023-09-27" @default.
• W334090985 title "Semi-parametric estimation of direct and indirect effects in the COMBINE (Combining Medications and Behavioral Interventions for Alcoholism) Study" @default.
• W334090985 cites W1497943959 @default.
• W334090985 cites W1517123085 @default.
• W334090985 cites W1525651898 @default.
• W334090985 cites W1551052402 @default.
• W334090985 cites W1553583298 @default.
• W334090985 cites W1569134566 @default.
• W334090985 cites W1839496149 @default.
• W334090985 cites W1925623703 @default.
• W334090985 cites W1952531728 @default.
• W334090985 cites W1964130757 @default.
• W334090985 cites W1964806926 @default.
• W334090985 cites W1965273569 @default.
• W334090985 cites W1969168891 @default.
• W334090985 cites W1971440513 @default.
• W334090985 cites W1977850625 @default.
• W334090985 cites W1979175134 @default.
• W334090985 cites W1981614424 @default.
• W334090985 cites W1981938399 @default.
• W334090985 cites W1995605212 @default.
• W334090985 cites W1999347062 @default.
• W334090985 cites W2006992423 @default.
• W334090985 cites W2007429684 @default.
• W334090985 cites W2014344383 @default.
• W334090985 cites W2016468054 @default.
• W334090985 cites W2019139715 @default.
• W334090985 cites W2024790117 @default.
• W334090985 cites W2026209943 @default.
• W334090985 cites W2032829907 @default.
• W334090985 cites W2033122986 @default.
• W334090985 cites W2038702827 @default.
• W334090985 cites W2039993999 @default.
• W334090985 cites W2042119083 @default.
• W334090985 cites W2043239339 @default.
• W334090985 cites W2044010874 @default.
• W334090985 cites W2044223859 @default.
• W334090985 cites W2048466053 @default.
• W334090985 cites W2049032077 @default.
• W334090985 cites W2050026656 @default.
• W334090985 cites W2050211235 @default.
• W334090985 cites W2050951233 @default.
• W334090985 cites W2055734645 @default.
• W334090985 cites W2056610139 @default.
• W334090985 cites W2062086084 @default.
• W334090985 cites W2063425068 @default.
• W334090985 cites W2065145667 @default.
• W334090985 cites W2066906665 @default.
• W334090985 cites W2067227935 @default.
• W334090985 cites W2068530297 @default.
• W334090985 cites W2068719957 @default.
• W334090985 cites W2072468543 @default.
• W334090985 cites W2074320107 @default.
• W334090985 cites W2079601465 @default.
• W334090985 cites W2082206299 @default.
• W334090985 cites W2082229496 @default.
• W334090985 cites W2086383240 @default.
• W334090985 cites W2088377182 @default.
• W334090985 cites W2088861378 @default.
• W334090985 cites W2092262854 @default.
• W334090985 cites W2092264417 @default.
• W334090985 cites W2093336948 @default.
• W334090985 cites W2093559862 @default.
• W334090985 cites W2096533075 @default.
• W334090985 cites W2097550528 @default.
• W334090985 cites W2100813505 @default.
• W334090985 cites W2101372918 @default.
• W334090985 cites W2104372273 @default.
• W334090985 cites W2104538950 @default.
• W334090985 cites W2107117723 @default.
• W334090985 cites W2107970821 @default.
• W334090985 cites W2111774737 @default.
• W334090985 cites W2113580683 @default.
• W334090985 cites W2117060002 @default.
• W334090985 cites W2118994821 @default.
• W334090985 cites W2123343901 @default.
• W334090985 cites W2124015705 @default.
• W334090985 cites W2126294191 @default.
• W334090985 cites W2128246345 @default.
• W334090985 cites W2131289444 @default.
• W334090985 cites W2131568786 @default.
• W334090985 cites W2133661531 @default.
• W334090985 cites W2138741431 @default.
• W334090985 cites W2144724143 @default.
• W334090985 cites W2148088954 @default.
• W334090985 cites W2150715760 @default.
• W334090985 cites W2154353860 @default.
• W334090985 cites W2154570367 @default.
• W334090985 cites W2157113531 @default.
• W334090985 cites W2160610058 @default.
• W334090985 cites W2162642430 @default.
• W334090985 cites W2167896264 @default.
• W334090985 cites W2171098630 @default.
• W334090985 cites W2171727981 @default.
• W334090985 cites W2214185525 @default.
• W334090985 cites W2275832530 @default.

• next