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- W33415263 abstract "9 Objectives: Bone marrow stem cells (BMSC) may potentially be used for regeneration of damaged myocardium in patients with ischemic heart disease. Whole body distribution after intracoronary delivery has been described by several authors. We present our experience with intramyocardial distribution of BMSC and its relation to changes of ejection fraction (EF) upon follow-up. Methods: We evaluated 8 patients with ischemic heart disease: 4 pts after remote myocardial infarction (RMI) and 4 pts with acute myocardial ischemia (AMI) treated with emergency PCI. There were 7 men and 1 woman, mean age 57 (45 to 67) y. Autologous bone marrow cells were labeled with Tc99m HMPAO and delivered into the left anterior descending coronary artery in the order of 108 cells via angioplastic catheter. Distribution was assessed visually on SPECT images performed 2 hours later. Perfusion was assesses with Tc99m MIBI and metabolism with F18 FDG in 4 pts. EF was measured by echo or contrast ventriculography at the time of BMSC delivery and several (2 to 18) months later. Results: 2 pts post RMI had an apical scar and viable myocardium in the antero-septal wall. BMSC localized exactly to these sites post delivery. EF increased from 28% to 40% (in 2 months, pt 1) and from 35% to 45% (in 18 months, pt 2). One pt had only a scar infero-septally, no BMSC accumulation and no change in EF (still 35% in 12 months), one pt had diffuse hypokinesia, no BMSC accumulation and no change in EF (still 35% in 8 months). 4 pts with AMI had hypo/akinesia apico-antero-septally. BMSC localized exactly to these sites post delivery in 3 pts and only to the septum in 1 pt. In 3 pts EF increased (35% to 45% in 4 months, 45% to 72% in 4 months, 45% to 60% in 11 months); 1 pt remained stable (EF of 50% in 5 months). Conclusions: It appears that BMSC localize only in at least partially viable myocardium and that the increase in EF depends on BMSC accumulation. Nevertheless, in 1 pt with AMI, no change in EF was detected despite BMSC distribution exactly to the site of hypokinesia." @default.
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- W33415263 date "2007-05-01" @default.
- W33415263 modified "2023-10-16" @default.
- W33415263 title "Intramyocardial distribution of bone marrow stem cells implanted into coronary artery in patients with acute or chronic myocardial infarction and its relation to the change of left ventricular function during follow-up" @default.
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