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- W334420719 startingPage "33" @default.
- W334420719 abstract "This chapter discusses the non-nucleoside reverse transcriptase inhibitors (NNRTI), which is a valuable component of first-line highly active antiretroviral therapy (HAART) today. Reverse transcriptase (RT) is an essential enzyme in the replication cycle of HIV. Several high-resolution structures representing the different intermediates in the polymerization reaction are available for human immunodeficiency virus type 1 (HIV-1) RT. Rilpivirine is currently in phase IIb clinical trials for treatment of HIV-1 infection in treatment-naive subjects. With the widespread use of anti-HIV therapy, resistance has grown steadily and is now common among treatment-experienced HIV-infected patients, with NNRTI resistance occurring in 20 to 30% of patients. This has changed with the DUET-1 and DUET-2 trials, two large phase III clinical trials that examined the efficacy of etravirine in treatment-resistant HIV-1-infected patients. K103N and Y181C were the first NNRTI mutations to be identified and to date are among the most prevalent in clinical HIV-1 isolates. They have been observed in patients failing on nevirapine, efavirenz, or delavirdine, and the clinical utility of these drugs is hampered by the presence of a single K103N or Y181C mutation. Recently, predictors of virologic response to etravirine were identified based on pooled data from DUET-1 and DUET-2." @default.
- W334420719 created "2016-06-24" @default.
- W334420719 creator A5015140638 @default.
- W334420719 creator A5021687135 @default.
- W334420719 creator A5024441137 @default.
- W334420719 creator A5049377323 @default.
- W334420719 creator A5073105044 @default.
- W334420719 date "2014-04-30" @default.
- W334420719 modified "2023-09-27" @default.
- W334420719 title "Human Immunodeficiency Virus Type 1 Non-Nucleoside Reverse Transcriptase Inhibitors" @default.
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