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- W334680784 abstract "Objective To investigate the inhibitory effect of the S-adenosylmethionine decarboylase(SAMDC)gene silencing on proliferation and invasion of breast cancer MCF-7 cells.Methods Breast cancer MCF-7 cells were transfected with a short hairpin RNA eukaryotic expression vector against SAMDC(pGPU6-SAMDC).The effect of suppressing proliferation of MCF-7 cells was detected by cell proliferation assay(CCK-8)and cell cycle analysis.Semi-quantitative RT-PCR analysis of mRNA and western blot analysis of proteins were used to determine expression of the SAMDC gene.The invasive ability of breast cancer MCF-7 cells was assessed by invasion assay in vitro.Results After the shRNA expression vector was transfected into breast cancer MCF-7 cells,the growth and invasive ability of MCF-7cells were significantly inhibited,and the proliferation of cells was decreased by 37%.Gene expression of SAMDC in MCF-7 cells was also significantly inhibited,of mRNA was inhibited by 43.8% and of protein was inhibited by 66.5%.Moreover,the proportion of MCF-7 cells in the G0/G1 phase was increased.Conclusion The shRNA of the SAMDC gene can effectively inhibit the proliferation and invasion of MCF-7 cells and is a potential target in gene therapy of breast cancer." @default.
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- W334680784 date "2009-01-01" @default.
- W334680784 modified "2023-09-26" @default.
- W334680784 title "Gene silencing of S-adenosylmethionine decarboylase inhibits growth of breast cancer MCF-7 cells." @default.
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