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- W33503833 abstract "While much information has accumulated on synthesis and inactivation of cyclo-oxygenase-derived products of arachidonate metabolism in the gastrointestinal tractl,2, only limited data are available on transformation of fatty acids via lipoxygenase pathways in this organ. Bennett et al3. and Hawkey et al4. have demonstrated that human colonic mucosa has the capacity to convert exogenous arachidonic acid to various hydroxy fatty acids. Increased synthesis of leukotriene (LT)B4 was found in colonic mucosa of patients with chronic inflammatory bowel disease5 as well as in experimental models of colonic inflammation6,7. We have studied formation of LTB4 and sulfidopeptide (SP)-LT by various tissues of the gastrointestinal tract of guinea pig and man and its modification by anti-inflammatory drugs." @default.
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- W33503833 date "1987-01-01" @default.
- W33503833 modified "2023-09-26" @default.
- W33503833 title "Leukotriene formation in the gastrointestinal tract and effects of anti-inflammatory drugs" @default.
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- W33503833 doi "https://doi.org/10.1007/978-94-010-9775-8_9" @default.
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