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- W335085841 abstract "A self-assembly and pH-sensitive drug release system that is based on aniline pentamer (AP) as a shell conjugated to polyethylene glycol (PEG)-modified dendrimers (PAMAM) with doxorubicin (DOX) (DOX-PEG-PAMAM-AP) has been constructed and characterized. First of all, the higher generations (G = 5) are demonstrated to self-assemble into bilayer vesicles owing to the strong tendency of the AP to form PAMAM-AP G5. Subsequently, PAMAM-AP G5 modified hydrophilic and biocompatibility segment PEG synthesis of PEG-PAMAM-AP G5. Finally, load with the anticancer drug (DOX) to synthesis DOX-PEG-PAMAM-AP G5. The use of amphiphilic characteristics form these aggregations as new drug carrier to explore the ability to cytotoxicity of human breast cancer cells, and compare the drug release efficiency." @default.
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- W335085841 date "2014-01-01" @default.
- W335085841 modified "2023-09-23" @default.
- W335085841 title "Synthesis and Characterization of Novel Self-assembly and Ph-Sensitive Anticancer Drug Carriers: (PAMAM-AP)-Modified PEG Loading with DOX" @default.
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- W335085841 doi "https://doi.org/10.1007/978-3-319-02913-9_178" @default.
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