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- W335199986 abstract "ABSTRACT Bradykinin (BK) liberates nitric oxide, prostacyclin, and tissue plasminogen activator from endothelial cells. We hypothesized that BK B2 receptor KO mice (BKB2R-/-) have increased thrombosis risk. Paradoxically, the BKB2R-/- have long bleeding times and delayed carotid artery thrombosis, 78±6.7 min vs 31±2.7 min control. The mechanism(s) for thrombosis protection was sought. In BKB2R-/- plasma coagulation, fibrinolysis and anticoagulant proteins are normal except for an increased prekallikrein and decreased factor XI. BKB2R-/- have elevated BK 1-5, (160±75 fmol/ml vs 44±29 fmol/ml control) and angiotensin II (182±41 pg/ml vs 49±7 pg/ml control). Ramipril treatment shortens vessel occlusion time. BKB2R-/- have elevated plasma 6-keto-PGF 1α (666±232 ng/ml vs 23±5.3 ng/ml control) and serum nitrate (61±5.3 μ M vs 24±1.8 μ M control). Treatment with L-NAME or nimesulide shortens the thrombosis time. BKB2R-/- have increased angiotensin receptor 2 (AT 2 R) mRNA and protein expression. Treatment with an AT" @default.
- W335199986 created "2016-06-24" @default.
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- W335199986 date "2013-01-01" @default.
- W335199986 modified "2023-09-27" @default.
- W335199986 title "increased nitric oxide and prostacyclin Bradykinin B2 receptor knockout mice are protected from thrombosis by" @default.
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