Matches in SemOpenAlex for { <https://semopenalex.org/work/W335316939> ?p ?o ?g. }
- W335316939 endingPage "663" @default.
- W335316939 startingPage "654" @default.
- W335316939 abstract "Imatinib mesylate, a selective tyrosine kinase inhibitor, is the first line treatment against chronic myelogenous leukemia and gastrointestinal stromal tumors. The aim of the present study is to investigate the effects of imatinib mesylate on the pregnant rats and their fetuses. Pregnant rats were divided into three groups; the first group served as a control group. The second and third groups were orally administered imatinib at doses of 36 mg/kg body weight or 54 mg/kg b.wt. on gestation days (SDs) 6 through 13 or SDs 13 through 19, respectively. All animals were sacrificed on the 20th day of gestation. Treatment with imatinib caused a reduction of maternal body weight gain, uterine and placental weights, increased rate of abortion and fetal resorptions. High dose of imatinib caused fetal congenital deformities represented in harelip, contraction of the fore limbs, and paralysis of the hind limbs, exencephaly, encephalocoele and distended abdominal wall, besides occurrence of wavy ribs and absence of other ribs in addition to skeletal growth retardation and lack of ossification of the most skeletal elements. The present work concluded that imatinib is teratogenic when given orally to pregnant rats at 54 mg/kg b.wt. and causes direct maternal or developmental toxicity." @default.
- W335316939 created "2016-06-24" @default.
- W335316939 creator A5029114262 @default.
- W335316939 creator A5040193556 @default.
- W335316939 creator A5040872224 @default.
- W335316939 creator A5065926826 @default.
- W335316939 date "2015-01-01" @default.
- W335316939 modified "2023-10-04" @default.
- W335316939 title "The teratogenic effects of imatinib mesylate on rat fetuses" @default.
- W335316939 cites W1511223524 @default.
- W335316939 cites W181292466 @default.
- W335316939 cites W186739404 @default.
- W335316939 cites W1927701703 @default.
- W335316939 cites W1963988805 @default.
- W335316939 cites W1970595617 @default.
- W335316939 cites W1971056497 @default.
- W335316939 cites W1980361869 @default.
- W335316939 cites W1986305718 @default.
- W335316939 cites W2003356109 @default.
- W335316939 cites W2017628148 @default.
- W335316939 cites W2020367573 @default.
- W335316939 cites W2038910221 @default.
- W335316939 cites W2048823662 @default.
- W335316939 cites W2050290229 @default.
- W335316939 cites W2051713698 @default.
- W335316939 cites W2057154300 @default.
- W335316939 cites W2065725554 @default.
- W335316939 cites W2069502117 @default.
- W335316939 cites W2081694482 @default.
- W335316939 cites W2082580993 @default.
- W335316939 cites W2087017705 @default.
- W335316939 cites W2087101501 @default.
- W335316939 cites W2090004346 @default.
- W335316939 cites W2098435910 @default.
- W335316939 cites W2098666353 @default.
- W335316939 cites W2100537270 @default.
- W335316939 cites W2102012621 @default.
- W335316939 cites W2107268345 @default.
- W335316939 cites W2112355756 @default.
- W335316939 cites W2123291552 @default.
- W335316939 cites W2126592101 @default.
- W335316939 cites W2140279988 @default.
- W335316939 cites W2151028908 @default.
- W335316939 cites W2165968465 @default.
- W335316939 cites W2261840157 @default.
- W335316939 cites W2416072608 @default.
- W335316939 cites W2474717961 @default.
- W335316939 cites W72032912 @default.
- W335316939 doi "https://doi.org/10.1016/j.toxrep.2015.05.001" @default.
- W335316939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5598385" @default.
- W335316939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28962401" @default.
- W335316939 hasPublicationYear "2015" @default.
- W335316939 type Work @default.
- W335316939 sameAs 335316939 @default.
- W335316939 citedByCount "15" @default.
- W335316939 countsByYear W3353169392016 @default.
- W335316939 countsByYear W3353169392017 @default.
- W335316939 countsByYear W3353169392019 @default.
- W335316939 countsByYear W3353169392020 @default.
- W335316939 countsByYear W3353169392021 @default.
- W335316939 countsByYear W3353169392022 @default.
- W335316939 countsByYear W3353169392023 @default.
- W335316939 crossrefType "journal-article" @default.
- W335316939 hasAuthorship W335316939A5029114262 @default.
- W335316939 hasAuthorship W335316939A5040193556 @default.
- W335316939 hasAuthorship W335316939A5040872224 @default.
- W335316939 hasAuthorship W335316939A5065926826 @default.
- W335316939 hasBestOaLocation W3353169391 @default.
- W335316939 hasConcept C126322002 @default.
- W335316939 hasConcept C134018914 @default.
- W335316939 hasConcept C172680121 @default.
- W335316939 hasConcept C2776960273 @default.
- W335316939 hasConcept C2777583451 @default.
- W335316939 hasConcept C2778461978 @default.
- W335316939 hasConcept C2778729363 @default.
- W335316939 hasConcept C2779234561 @default.
- W335316939 hasConcept C2781052626 @default.
- W335316939 hasConcept C3019892230 @default.
- W335316939 hasConcept C42407357 @default.
- W335316939 hasConcept C46973012 @default.
- W335316939 hasConcept C54355233 @default.
- W335316939 hasConcept C65290608 @default.
- W335316939 hasConcept C71924100 @default.
- W335316939 hasConcept C86803240 @default.
- W335316939 hasConceptScore W335316939C126322002 @default.
- W335316939 hasConceptScore W335316939C134018914 @default.
- W335316939 hasConceptScore W335316939C172680121 @default.
- W335316939 hasConceptScore W335316939C2776960273 @default.
- W335316939 hasConceptScore W335316939C2777583451 @default.
- W335316939 hasConceptScore W335316939C2778461978 @default.
- W335316939 hasConceptScore W335316939C2778729363 @default.
- W335316939 hasConceptScore W335316939C2779234561 @default.
- W335316939 hasConceptScore W335316939C2781052626 @default.
- W335316939 hasConceptScore W335316939C3019892230 @default.
- W335316939 hasConceptScore W335316939C42407357 @default.
- W335316939 hasConceptScore W335316939C46973012 @default.
- W335316939 hasConceptScore W335316939C54355233 @default.
- W335316939 hasConceptScore W335316939C65290608 @default.