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- W335352502 abstract "Abstract : It has been suggested that women who metabolize a larger proportion of their natural estrogen via the 16%-hydroxy pathway may be at significantly elevated risk of breast cancer compared to women who metabolize proportionally more estrogen via the 2-hydroxy pathway. This study evaluates whether the ratios of 16a-OHEl to 2-OHEl are higher in urine of premenopausal women at 'high' than at 'low' familiar risk of breast cancer; and whether the ratio is elevated in cases independent of total urinary estrone (E1), estradiol (E2) and estriol (E3). Early morning urine samples are collected from 100 premenopausal women at 'high' and 100 premenopausal women at 'low' risk of breast cancer. All subjects are sisters or daughters of subjects participating in one of three case-control studies of breast cancer at our institution. Five estrogen metabolites in urine are determined: 1 6a-OHE 1, OHE 1, El, E2 and E3 conjugates. The data collection is in progress." @default.
- W335352502 created "2016-06-24" @default.
- W335352502 creator A5078785349 @default.
- W335352502 date "1995-10-01" @default.
- W335352502 modified "2023-09-24" @default.
- W335352502 title "Estrogen Metabolism and Familial Risk of Breast Cancer." @default.
- W335352502 doi "https://doi.org/10.21236/ada306474" @default.
- W335352502 hasPublicationYear "1995" @default.
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