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- W335530974 abstract "This chapter focuses on the partner-switching mechanism, showing how signaling versatility is achieved and outlining the questions about network function that remain to be answered. A short section at the end of the chapter summarizes the roles of general stress regulons in the physiology of gram-positive organisms that possess sB, or σB-like factors. In Bacillus subtilis, RsbW has two activities in unstressed cells: (i) as an anti-sigma factor it binds σB and prevents its association with RNA polymerase; and (ii) as a serine kinase it specifically phosphorylates and inactivates its own antagonist, the RsbV anti- anti-sigma. Three single-domain anti-anti- sigma factors of Mycobacterium tuberculosis have atypical N-terminal extensions rich in serine and threonine residues, allowing their interactions to be controlled by a unique mechanism that may affect σF activity. In many gram-positive bacteria σB is a master regulator of a general stress modulon that closely interacts with other global systems. Investigation of the roles of genes in the modulon can provide a unique perspective regarding the physiological changes that promote stress resistance. How σB signaling networks sense activating stresses remains an open question. Given the wide distribution of the recognized sensing modules and their association with different output domains, this question is relevant to many signaling pathways." @default.
- W335530974 created "2016-06-24" @default.
- W335530974 creator A5013607579 @default.
- W335530974 date "2014-04-09" @default.
- W335530974 modified "2023-10-10" @default.
- W335530974 title "General Stress Response in<i>Bacillus subtilis</i>and Related Gram-Positive Bacteria" @default.
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