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- W335532017 abstract "The bufodienolides are natriuretic steroids, which also have the capacity to cause vasoconstriction, and are cardiac inotropes. Their mechanism of action appears to be related to their ability to inhibit Na+/K+ ATPase. The actions of one of these compounds, marinobufagenin (MBG), have been investigated in a rat model of preeclampsia, an example of volume expansion-mediated hypertension. The urinary excretion of MGB is increased in this model. Furthermore, this increment in its excretion occurs prior to the development of hypertension and proteinuria. The animals also demonstrate intrauterine growth restriction. Studies of the effect of MBG on cytotrophoblast cells reveal that MGB inhibits the migration, proliferation and invasion of these cells. We propose that MGB is an important etiologic factor in at least some forms of preeclampsia and that the level of its excretion in the urine may prove to be of diagnostic value." @default.
- W335532017 created "2016-06-24" @default.
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- W335532017 date "2008-01-01" @default.
- W335532017 modified "2023-09-23" @default.
- W335532017 title "Vascular effects of the bufodienolides." @default.
- W335532017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2394688" @default.
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