Matches in SemOpenAlex for { <https://semopenalex.org/work/W33565408> ?p ?o ?g. }
- W33565408 abstract "The development of inhibitors of sterol C 14 demethylase in fungi has provided a rich source of drugs and pesticides. These compounds have been found to be potent inhibitors of a wide variety of fungi that have membrane sterols. However, a number of challenges remain as novel fungal infections occur in immunocompromised patients and with the occurrence of disease resistance. The latter is currently more pronounced as a problem in agriculture, but with exposure of humans to prolonged chemotherapy increasing reports are likely in this area as well. Surprisingly, although the commercial importance of the azole antifungals has been apparent for more than 20 years the molecular details of tolerance and mode of action are only now becoming clearly defined. Many of these phenomena are now amenable to modern molecular analysis and should allow these studies to be completed." @default.
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- W33565408 date "1992-01-01" @default.
- W33565408 modified "2023-09-25" @default.
- W33565408 title "Sterol 14α-Demethylase: Target of the Azole Antifungal Agents" @default.
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- W33565408 doi "https://doi.org/10.1007/978-1-4899-6729-9_9" @default.
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