Matches in SemOpenAlex for { <https://semopenalex.org/work/W335682710> ?p ?o ?g. }
- W335682710 endingPage "151" @default.
- W335682710 startingPage "137" @default.
- W335682710 abstract "Astaxanthin, a carotenoid extensively found in marine organisms and increasingly used as a dietary supplement, has been reported to have neuroprotective effect. In this study, the neuroprotective effects and mechanisms of astaxanthin against glutamate-induced neurotoxicity were explored. The results showed that pretreatment with astaxanthin inhibited neuronal PC12 cell death induced by L-glutamate and reduced the production of reactive oxygen species (ROS) significantly. Astaxanthin prevented glutamate-induced apoptosis by depressing the elevation of Bax/Bcl-2 ratio, caspase-3 activation and Ca2+ influx. Moreover, the loss of mitochondrial membrane potential (MMP) as well as the activation of ROS associated NF-κB and MAPK pathways were also inhibited upon treatment with astaxanthin. Therefore, the neuroprotective effects reflected the ability of astaxanthin in the regulation of multiple signaling pathways that protect mitochondria as well as cellular damage induced by L-glutamate. Thus, astaxanthin has the potential to be used as a prophylactic or remediation agent against neuronal disorders." @default.
- W335682710 created "2016-06-24" @default.
- W335682710 creator A5015210484 @default.
- W335682710 creator A5026433926 @default.
- W335682710 creator A5041252924 @default.
- W335682710 creator A5046597133 @default.
- W335682710 creator A5078526337 @default.
- W335682710 date "2015-06-01" @default.
- W335682710 modified "2023-10-17" @default.
- W335682710 title "Astaxanthin protects PC12 cells from glutamate-induced neurotoxicity through multiple signaling pathways" @default.
- W335682710 cites W1534551308 @default.
- W335682710 cites W1602087894 @default.
- W335682710 cites W1839369514 @default.
- W335682710 cites W1965070196 @default.
- W335682710 cites W1966895792 @default.
- W335682710 cites W1973893152 @default.
- W335682710 cites W1975114184 @default.
- W335682710 cites W1975938392 @default.
- W335682710 cites W1978266275 @default.
- W335682710 cites W1979958463 @default.
- W335682710 cites W1985761252 @default.
- W335682710 cites W1986170848 @default.
- W335682710 cites W1988692831 @default.
- W335682710 cites W1994025158 @default.
- W335682710 cites W1996281559 @default.
- W335682710 cites W2012405841 @default.
- W335682710 cites W2013667808 @default.
- W335682710 cites W2023621913 @default.
- W335682710 cites W2026155769 @default.
- W335682710 cites W2026871529 @default.
- W335682710 cites W2031646822 @default.
- W335682710 cites W2036645967 @default.
- W335682710 cites W2050788134 @default.
- W335682710 cites W2051986302 @default.
- W335682710 cites W2055615470 @default.
- W335682710 cites W2057113140 @default.
- W335682710 cites W2058116127 @default.
- W335682710 cites W2060952492 @default.
- W335682710 cites W2068065815 @default.
- W335682710 cites W2071292135 @default.
- W335682710 cites W2072760949 @default.
- W335682710 cites W2075477970 @default.
- W335682710 cites W2076314669 @default.
- W335682710 cites W2080210110 @default.
- W335682710 cites W2081566259 @default.
- W335682710 cites W2081769747 @default.
- W335682710 cites W2087467518 @default.
- W335682710 cites W2087877138 @default.
- W335682710 cites W2092173424 @default.
- W335682710 cites W2094939646 @default.
- W335682710 cites W2095200269 @default.
- W335682710 cites W2124281128 @default.
- W335682710 cites W2126475226 @default.
- W335682710 cites W2135250775 @default.
- W335682710 cites W2140660632 @default.
- W335682710 cites W2148933367 @default.
- W335682710 cites W2149967205 @default.
- W335682710 cites W2154385453 @default.
- W335682710 cites W2154439380 @default.
- W335682710 cites W2154899903 @default.
- W335682710 cites W2170806182 @default.
- W335682710 cites W2312460490 @default.
- W335682710 cites W2316846157 @default.
- W335682710 doi "https://doi.org/10.1016/j.jff.2015.04.008" @default.
- W335682710 hasPublicationYear "2015" @default.
- W335682710 type Work @default.
- W335682710 sameAs 335682710 @default.
- W335682710 citedByCount "25" @default.
- W335682710 countsByYear W3356827102015 @default.
- W335682710 countsByYear W3356827102016 @default.
- W335682710 countsByYear W3356827102017 @default.
- W335682710 countsByYear W3356827102018 @default.
- W335682710 countsByYear W3356827102019 @default.
- W335682710 countsByYear W3356827102020 @default.
- W335682710 countsByYear W3356827102021 @default.
- W335682710 countsByYear W3356827102022 @default.
- W335682710 countsByYear W3356827102023 @default.
- W335682710 crossrefType "journal-article" @default.
- W335682710 hasAuthorship W335682710A5015210484 @default.
- W335682710 hasAuthorship W335682710A5026433926 @default.
- W335682710 hasAuthorship W335682710A5041252924 @default.
- W335682710 hasAuthorship W335682710A5046597133 @default.
- W335682710 hasAuthorship W335682710A5078526337 @default.
- W335682710 hasConcept C170493617 @default.
- W335682710 hasConcept C178790620 @default.
- W335682710 hasConcept C185592680 @default.
- W335682710 hasConcept C190283241 @default.
- W335682710 hasConcept C25498285 @default.
- W335682710 hasConcept C2779491297 @default.
- W335682710 hasConcept C2780962900 @default.
- W335682710 hasConcept C28781525 @default.
- W335682710 hasConcept C29730261 @default.
- W335682710 hasConcept C48349386 @default.
- W335682710 hasConcept C55493867 @default.
- W335682710 hasConcept C61174792 @default.
- W335682710 hasConcept C86803240 @default.
- W335682710 hasConcept C95444343 @default.
- W335682710 hasConcept C98274493 @default.