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- W335857675 abstract "Using fusions between the Escherichia coli genes argI and lacZ, it has been demonstrated that ribosomal frameshifting occurs at a frequency of between 3% and 16% within the argI mRNA, soon after the initiation codon. The frameshift involves a phenylalanyl-tRNA shifting into the +1 frame at the sequence UUU-U/C. The shift does not occur if the in-frame phenylalanine codon UUU is replaced by UUC. The level of frameshifting is higher in dense cultures and is not dependent on phenylalanine starvation. In the wild-type argI gene this frameshifting event would be an error, leading to a truncated, non-functional protein. Therefore, it is unlike the numerous examples of required frameshifting events that have been described in other genes." @default.
- W335857675 created "2016-06-24" @default.
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- W335857675 date "1994-07-01" @default.
- W335857675 modified "2023-10-10" @default.
- W335857675 title "A ribosomal frameshifting error during translation of the argl mRNA of Escherichla coli" @default.
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- W335857675 doi "https://doi.org/10.1007/bf00280474" @default.
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