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- W335862087 abstract "This chapter discusses the studies analyzing nature and specificity of anti-γ-globulin factors in tissue. Using direct mixed agglutination, synovial tissue from 344 patients was tested. Of 86 patients with definite rheumatoid arthritis, 85 had activity in their tissues. Tissue from only two patients with other joint diseases showed activity. One of these patients had a tenosynovitis and the other a chronic nonspecific arthritis. The four patients from the autopsy group whose tissue showed activity had rheumatoid arthritis some years ago. The reactions are inhibited by denatured human and rabbit γ-globulin and by antiserum to γM globulin. The sections can be thoroughly washed in saline without reducing their activity. It was therefore concluded that the activity in tissue is dependent on rheumatoid factor bound in the tissue. In some experiments, the activity recorded using human and rabbit indicator systems was compared. The results illustrate three different patterns obtained. With tissue from most of the patients, the degree of activity recorded using the human indicator system corresponds to that obtained with the rabbit indicator system. However, with some tissues the activity against human indicator system was stronger than against the rabbit system and with others, the opposite was found." @default.
- W335862087 created "2016-06-24" @default.
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- W335862087 date "1971-01-01" @default.
- W335862087 modified "2023-10-18" @default.
- W335862087 title "NATURE AND SPECIFICITY OF ANTI-γ-GLOBULIN FACTORS IN TISSUE" @default.
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- W335862087 doi "https://doi.org/10.1016/b978-0-08-016451-9.50020-2" @default.
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