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• W336181703 abstract "Monospecific rabbit anti-human fetal antigen 1 (FA1), was used to examine the distribution of FA1 dur- ing the development of the human fetal pancreas and liver using an indirect immunoperoxidase technique. FAI was expressed by 94% of the glandular epithelial cells of the branching ducts in the pancreatic anlage at week 7 of gestation. This pattern changed during the de- velopment of the human pancreas, 64% of the glandular cells being FA1 positive at week 17 of gestation, decreas- ing to 11% in the infant (4 months after birth). In the infant and adults the FA1 expression was restricted to a subpopulation of fl-cells within the islets of Langerhans. Insulin immunoreactive cells were scattered throughout the epithelium of primitive branching pancreatic ducts at week 7 of gestation, well before the formation of islets. From the 7th through to the 17th week of gestation, FA1 was found in the cytoplasm of fetal hepatocytes, whereas no staining was observed in the liver from a 4-month-old infant. No FA1 expression was found in the epithelium of the developing gut. The present findings indicate that the glandular epithelial cells in the developing pancreas may serve as stern cells, which, if appropriately induced, may differentiate into endocrine cells. Fetal antigen 1 (FA1) may take part in or be a result of this differentiation." @default.
• W336181703 created "2016-06-24" @default.
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• W336181703 date "1993-01-01" @default.
• W336181703 modified "2023-09-27" @default.
• W336181703 title "Fetal antigen 1 (FA1) in the human cell type expression, topological and during development pancreas: quantitative variations" @default.
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• W336181703 hasPublicationYear "1993" @default.
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