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• W336312206 abstract "Antimony (Sb) has a long history in both the chemical and social literature. As a metalloid it is often found in the environment with Arsenic (As). Extended exposure in humans causes heart disease, lung disease, diarrhea, severe vomiting and ulcers. In plants, it inhibits early crop growth. A large body of data on bacterial response and mechanisms for detoxification also exists. In contrast, knowledge about how archaeal species respond to Sb is much less extensive. The model crenarchaeal organism Sulfolobus solfataricus, can survive in environments with high antimony concentrations, and the genetic and biochemical mechanisms responsible for antimony tolerance have yet to be reported. As a first step in bringing to light the biological response of S. solfataricus to antimony, a set of proteomic and chemical tagging experiments were undertaken. Twodimensional differential gel electrophoresis (2D-DIGE) showed a limited response from intracellular and membrane proteins with respect to their abundance. In contrast," @default.
• W336312206 created "2016-06-24" @default.
• W336312206 creator A5048711269 @default.
• W336312206 date "2014-01-01" @default.
• W336312206 modified "2023-09-23" @default.
• W336312206 title "PROTEOMICS AND IN VIVO LABELING OF PROTEIN THIOLS IN SULFOLOBUS SOLFATARICUS DURING EXPOSURE TO ANTIMONY" @default.
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