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- W336427092 abstract "Utilizing various blocked mutants in Micromonospora sagamiensis, biosynthesis of sagamicin and gentamicin was studied. Intermediates and shunt metabolites were isolated from the culture broths of the mutants and identified. Biotransformation of these compounds and other gentamicin components was investigated with the blocked mutants. The data allowed for reasonable charting of the major route of sagamicin-gentamicin synthesis by M. sagamiensis. New antibiotics containing 2-deoxv-scyllo-inosamine were found to be produced by a blocked mutant. These antibiotics, which were named SU-1, SU-2 and SUM-3, exhibited potent antibacterial activities. Mutants producing sisomicin-group of antibiotics, 3″-N-demethyl compounds and increased yields of sagamicin are described. KEYWORDS Antibiotic; aminoglycoside; gentamicin, sagamicin; biosynthesis; blocked mutant; biotransformation; fermentation." @default.
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- W336427092 date "1981-01-01" @default.
- W336427092 modified "2023-09-27" @default.
- W336427092 title "FERMENTATION AND BIOSYNTHESIS OF SAGAMICIN AND RELATED AMINOGLYCOSIDES IN MICROMONOSPORA SAGAMIENSIS" @default.
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- W336427092 doi "https://doi.org/10.1016/b978-0-08-025385-5.50027-4" @default.
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