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- W337470511 abstract "Evidence is reviewed which implicates a modulatory role for magnesium (Mg) in the control of arterial blood pressure, vascular tone and lipid metabolism. The evidence is beginning to become persuasive in implicating lower than normal dietary intake of Mg in the etiology of some forms of hypertension, ischemic heart disease (IHD) and atherosclerosis. Hypomagnesemic states in hospitalized patients, particularly those subjects with cardiovascular disease, is becoming more frequent and a serious risk factor for cardiac arrhythmias and stroke. Experimental evidence is presented which demonstrates that Mg deficiency can lead to hypertension, atheromas and coronary vasospasm. Therapy with Mg in several forms of experimental hypertension and atherosclerosis is efficacious. Evidence is also presented to indicate that the (Mg/sup 2+/)/degree/ controls myocardial cellular bioenergetics at the cytosolic and mitochondrial levels. Lastly, the data implicates Mg/sup 2+/ as a true intracellular regulatory cation and most likely as a second messenger." @default.
- W337470511 created "2016-06-24" @default.
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- W337470511 date "1988-01-01" @default.
- W337470511 modified "2023-09-23" @default.
- W337470511 title "Role of magnesium in etiology of hypertension and atherosclerosis: is Mg/sup 2+/ a second messenger in cardiac and vascular muscle" @default.
- W337470511 hasPublicationYear "1988" @default.
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