Matches in SemOpenAlex for { <https://semopenalex.org/work/W33778274> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W33778274 endingPage "120" @default.
- W33778274 startingPage "115" @default.
- W33778274 abstract "The ion channels underlying action potentials in excitable cells have an approximate four-fold symmetry with each subunit, or homologous domain, surrounding a central permeation pathway (pore) that extends across the lipid bilayer membrane. Each subunit or domain contains a positively charged transmembrane segment, designated the S4 segment, that acts as a sensor of the membrane potential. The pore is lined by a selectivity filter at its external end and the four S6 transmembrane segments over most of its length. The S6 segments converge at their cytoplasmic ends to form the activation gate that opens and closes the pore. In the present work, we discuss the possible role of other putative voltage sensors in the channel, especially the S2 segment, and mechanisms for coupling S4 and S6 movement. Voltage-gated ion channels are responsible for generating action potentials in excitable cells. Understanding how they accomplish this feat has occupied scientists worldwide for the last half century. This quest has been aided by many technological breakthroughs, including the cloning and sequencing of many members of the superfamily of voltage-gated ion channels, which include sodium, potassium, and calcium channels. As a result of a deluge of 'structure-function' studies the main molecular participants in voltage-dependent gating are now established. An ion channel capable of voltage-dependent gating requires three molecular components: a selective permeation pathway (pore) through which privileged ions can diffuse across the membrane, a gate that permits or denies access to this pore, and a voltage sensor that moves in response to changes of membrane potential. A further requirement is that the voltage sensors and gates of the channel must be coupled, so that gates ultimately respond to changes of membrane potential by opening or closing. This article will describe these three molecular participants in voltage-dependent gating and" @default.
- W33778274 created "2016-06-24" @default.
- W33778274 creator A5006874020 @default.
- W33778274 creator A5043534173 @default.
- W33778274 creator A5080418456 @default.
- W33778274 date "2005-12-09" @default.
- W33778274 modified "2023-09-23" @default.
- W33778274 title "Molecular Participants in Voltage-Dependent Gating" @default.
- W33778274 cites W1969577194 @default.
- W33778274 cites W1970264142 @default.
- W33778274 cites W1974672405 @default.
- W33778274 cites W1998719957 @default.
- W33778274 cites W2009675168 @default.
- W33778274 cites W2035066043 @default.
- W33778274 cites W2053035210 @default.
- W33778274 cites W2089036242 @default.
- W33778274 cites W2093768785 @default.
- W33778274 cites W2126725618 @default.
- W33778274 cites W2139852988 @default.
- W33778274 cites W4253271002 @default.
- W33778274 doi "https://doi.org/10.1007/0-387-27424-3_12" @default.
- W33778274 hasPublicationYear "2005" @default.
- W33778274 type Work @default.
- W33778274 sameAs 33778274 @default.
- W33778274 citedByCount "0" @default.
- W33778274 crossrefType "book-chapter" @default.
- W33778274 hasAuthorship W33778274A5006874020 @default.
- W33778274 hasAuthorship W33778274A5043534173 @default.
- W33778274 hasAuthorship W33778274A5080418456 @default.
- W33778274 hasConcept C104292427 @default.
- W33778274 hasConcept C104317684 @default.
- W33778274 hasConcept C118892022 @default.
- W33778274 hasConcept C12554922 @default.
- W33778274 hasConcept C170493617 @default.
- W33778274 hasConcept C181911157 @default.
- W33778274 hasConcept C185592680 @default.
- W33778274 hasConcept C194544171 @default.
- W33778274 hasConcept C24530287 @default.
- W33778274 hasConcept C37088560 @default.
- W33778274 hasConcept C39944091 @default.
- W33778274 hasConcept C41625074 @default.
- W33778274 hasConcept C45516822 @default.
- W33778274 hasConcept C50254741 @default.
- W33778274 hasConcept C53465041 @default.
- W33778274 hasConcept C55493867 @default.
- W33778274 hasConcept C83743174 @default.
- W33778274 hasConcept C86803240 @default.
- W33778274 hasConceptScore W33778274C104292427 @default.
- W33778274 hasConceptScore W33778274C104317684 @default.
- W33778274 hasConceptScore W33778274C118892022 @default.
- W33778274 hasConceptScore W33778274C12554922 @default.
- W33778274 hasConceptScore W33778274C170493617 @default.
- W33778274 hasConceptScore W33778274C181911157 @default.
- W33778274 hasConceptScore W33778274C185592680 @default.
- W33778274 hasConceptScore W33778274C194544171 @default.
- W33778274 hasConceptScore W33778274C24530287 @default.
- W33778274 hasConceptScore W33778274C37088560 @default.
- W33778274 hasConceptScore W33778274C39944091 @default.
- W33778274 hasConceptScore W33778274C41625074 @default.
- W33778274 hasConceptScore W33778274C45516822 @default.
- W33778274 hasConceptScore W33778274C50254741 @default.
- W33778274 hasConceptScore W33778274C53465041 @default.
- W33778274 hasConceptScore W33778274C55493867 @default.
- W33778274 hasConceptScore W33778274C83743174 @default.
- W33778274 hasConceptScore W33778274C86803240 @default.
- W33778274 hasLocation W337782741 @default.
- W33778274 hasOpenAccess W33778274 @default.
- W33778274 hasPrimaryLocation W337782741 @default.
- W33778274 hasRelatedWork W155379114 @default.
- W33778274 hasRelatedWork W164173033 @default.
- W33778274 hasRelatedWork W1987496654 @default.
- W33778274 hasRelatedWork W1991248935 @default.
- W33778274 hasRelatedWork W1997867424 @default.
- W33778274 hasRelatedWork W2012306256 @default.
- W33778274 hasRelatedWork W2039010435 @default.
- W33778274 hasRelatedWork W2045493336 @default.
- W33778274 hasRelatedWork W2052272381 @default.
- W33778274 hasRelatedWork W2058986659 @default.
- W33778274 hasRelatedWork W2148368846 @default.
- W33778274 hasRelatedWork W2165546199 @default.
- W33778274 hasRelatedWork W2170352071 @default.
- W33778274 hasRelatedWork W2560761073 @default.
- W33778274 hasRelatedWork W2809956971 @default.
- W33778274 hasRelatedWork W2907771686 @default.
- W33778274 hasRelatedWork W3000844248 @default.
- W33778274 hasRelatedWork W3013083971 @default.
- W33778274 hasRelatedWork W3144541782 @default.
- W33778274 hasRelatedWork W3200577729 @default.
- W33778274 isParatext "false" @default.
- W33778274 isRetracted "false" @default.
- W33778274 magId "33778274" @default.
- W33778274 workType "book-chapter" @default.