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- W33789694 abstract "Three week old Sprague-Dawley derived NCTR-CD-23 strain male rats were divided into three groups of thirteen each. All animals were kept on copper-deficient diet (0.5 ppm copper). Group I received distilled-deionized water while groups II and III received distilled-deionized water containing 0.75 and 4.5 µg/ml of copper respectively. After 6 weeks on diet, 3 animals from each group were sacrificed to monitor their copper status. Paw volumes of the rest of the animals were measured and six animals in each group were injected with 0.5 mg of heat-killed M. tuberculosis finely suspended in 50 µl of Freund’s complete adjuvant (GIBCO #17-5721). The rest were used as controls. Paw volumes were again measured 7, 14 and 21 days later. Animals were found to grow normally and there were no significant differences in their hematological status. Copper concentrations on the day of injection were as follows in groups I, II and III, respectively: in plasma-0.07, 0.73 and 1.10 µg/ml; in liver-0.91, 2.76 and 4.15 µg/g; in brain-1.66, 2.13 and 2.63 µg/g. Paw swelling was maximum on day 14. On day 21 groups II and III had significant reduction of paw edema while group I showed no change (table I).KeywordsCopper ConcentrationAdjuvant ArthritisPlasma ZincCopper StatusDietary CopperThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W33789694 date "1982-01-01" @default.
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- W33789694 title "Effect of Dietary Copper on Adjuvant Arthritis in the Rat" @default.
- W33789694 doi "https://doi.org/10.1007/978-1-4612-5829-2_56" @default.
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