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- W337972323 abstract "Anoxic depolarization (AD) of cerebral cortex, a negative slow potential developing several minutes after interruption of cerebral blood flow and cessation of EEG activity, was described forty years ago by Leao (1947). This important paper followed shortly after discovery of spreading depression (SD) of EEG activity (Leao 1944) and demonstrated for the first time that the wavefront of reduced EEG amplitude propagating at a rate of 3 mm/min across the cortical surface of the rabbit brain is accompanied by a negative slow potential. It pointed out the essential similarity of the DC shifts occurring during SD and AD in the rabbit cerebral cortex but also showed important differences between the two phenomena: whereas during SD the negative slow potential coincides with the suppression of EEG activity, AD starts several minutes after complete disappearance of EEG during anoxia. This finding disproved the possibility that SD is a vascular phenomenon due to a propagating wave of vasoconstriction and oriented further research into the nature of both phenomena toward the underlying electrolyte shifts." @default.
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- W337972323 date "1988-01-01" @default.
- W337972323 modified "2023-10-17" @default.
- W337972323 title "Susceptibility to Spreading Depression and Anoxia: Regional Differences and Drug Control" @default.
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- W337972323 doi "https://doi.org/10.1007/978-1-4684-5562-5_27" @default.
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