Matches in SemOpenAlex for { <https://semopenalex.org/work/W338021218> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W338021218 abstract "The authors have shown that gangliosides inhibit the growth of IL 2-dependent T cells. Phorbol myristate acetate (PMA) was tested as a proliferative stimulus in an effort to isolate a protein kinase C (PKC)-activated pathway in these cells as a potential target for ganglioside inhibition. CT-6 murine T cells were cultured at 5 x 10/sup 4/ cells/ml in the presence of PMA, IL 2, or both, and in the presence or absence of gangliosides. PMA (1-20 nM) stimulated CT-6 cell division in IL 2-free media, as measured by increases in /sup 3/H-thymidine uptake or by actual cell counts. Inactive tumor promotors were ineffective stimulators of CT-6 growth. in time course studies, PMA induction paralleled IL 2 induction of growth, but the mitogenic index of 25% IL 2-containing media was from 1.3 to 2.1 times that of PMA. IL 2 and PMA-induced proliferation were not synergistic; rather, PMA reduced IL 2-stimulated growth. Various purified gangliosides inhibited PMA-induced proliferation; the (I)/sub 50/ of each ganglioside was similar comparing PMA and IL 2-induced growth. In both cases, GM/sub 2/ was the most potent inhibitor and neutral glycolipids were ineffective. The results suggest that a PKC-dependent pathway is functional in IL 2-dependent T cells,more » that maximal proliferation requires other events unrelated to PKC activation, and that the PKC pathway is a primary target of ganglioside inhibition in these cells.« less" @default.
- W338021218 created "2016-06-24" @default.
- W338021218 creator A5032620275 @default.
- W338021218 creator A5073139222 @default.
- W338021218 creator A5084445062 @default.
- W338021218 date "1986-05-01" @default.
- W338021218 modified "2023-09-23" @default.
- W338021218 title "Phorbol ester-induced proliferation of interleukin 2 (IL 2)-dependent murine T cells and inhibition by gangliosides" @default.
- W338021218 hasPublicationYear "1986" @default.
- W338021218 type Work @default.
- W338021218 sameAs 338021218 @default.
- W338021218 citedByCount "0" @default.
- W338021218 crossrefType "journal-article" @default.
- W338021218 hasAuthorship W338021218A5032620275 @default.
- W338021218 hasAuthorship W338021218A5073139222 @default.
- W338021218 hasAuthorship W338021218A5084445062 @default.
- W338021218 hasConcept C153911025 @default.
- W338021218 hasConcept C185592680 @default.
- W338021218 hasConcept C195794163 @default.
- W338021218 hasConcept C203014093 @default.
- W338021218 hasConcept C2776090121 @default.
- W338021218 hasConcept C2777331542 @default.
- W338021218 hasConcept C2777371288 @default.
- W338021218 hasConcept C2778690821 @default.
- W338021218 hasConcept C2779707156 @default.
- W338021218 hasConcept C2780043322 @default.
- W338021218 hasConcept C54355233 @default.
- W338021218 hasConcept C55493867 @default.
- W338021218 hasConcept C62112901 @default.
- W338021218 hasConcept C62478195 @default.
- W338021218 hasConcept C81885089 @default.
- W338021218 hasConcept C86803240 @default.
- W338021218 hasConcept C8891405 @default.
- W338021218 hasConcept C95444343 @default.
- W338021218 hasConceptScore W338021218C153911025 @default.
- W338021218 hasConceptScore W338021218C185592680 @default.
- W338021218 hasConceptScore W338021218C195794163 @default.
- W338021218 hasConceptScore W338021218C203014093 @default.
- W338021218 hasConceptScore W338021218C2776090121 @default.
- W338021218 hasConceptScore W338021218C2777331542 @default.
- W338021218 hasConceptScore W338021218C2777371288 @default.
- W338021218 hasConceptScore W338021218C2778690821 @default.
- W338021218 hasConceptScore W338021218C2779707156 @default.
- W338021218 hasConceptScore W338021218C2780043322 @default.
- W338021218 hasConceptScore W338021218C54355233 @default.
- W338021218 hasConceptScore W338021218C55493867 @default.
- W338021218 hasConceptScore W338021218C62112901 @default.
- W338021218 hasConceptScore W338021218C62478195 @default.
- W338021218 hasConceptScore W338021218C81885089 @default.
- W338021218 hasConceptScore W338021218C86803240 @default.
- W338021218 hasConceptScore W338021218C8891405 @default.
- W338021218 hasConceptScore W338021218C95444343 @default.
- W338021218 hasLocation W3380212181 @default.
- W338021218 hasOpenAccess W338021218 @default.
- W338021218 hasPrimaryLocation W3380212181 @default.
- W338021218 hasRelatedWork W1529173444 @default.
- W338021218 hasRelatedWork W1532422785 @default.
- W338021218 hasRelatedWork W1591967161 @default.
- W338021218 hasRelatedWork W1655566298 @default.
- W338021218 hasRelatedWork W1964292757 @default.
- W338021218 hasRelatedWork W1965565780 @default.
- W338021218 hasRelatedWork W1972105578 @default.
- W338021218 hasRelatedWork W1978036864 @default.
- W338021218 hasRelatedWork W1990238634 @default.
- W338021218 hasRelatedWork W2000013264 @default.
- W338021218 hasRelatedWork W2012668469 @default.
- W338021218 hasRelatedWork W2025669404 @default.
- W338021218 hasRelatedWork W2029031866 @default.
- W338021218 hasRelatedWork W2073888512 @default.
- W338021218 hasRelatedWork W2076694765 @default.
- W338021218 hasRelatedWork W2141206772 @default.
- W338021218 hasRelatedWork W2162636146 @default.
- W338021218 hasRelatedWork W2167756466 @default.
- W338021218 hasRelatedWork W2095425851 @default.
- W338021218 hasRelatedWork W2492765599 @default.
- W338021218 isParatext "false" @default.
- W338021218 isRetracted "false" @default.
- W338021218 magId "338021218" @default.
- W338021218 workType "article" @default.