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- W338201272 abstract "Objective To investigate the relationship between gastric pH value,gastric bacterial number and pulmonary bacterial number of rats of different ages as well as whether bacterial overgrowth could cause gastrointestinal and pulmonary infection.Method 30 Wister rats,among which 20 were at 3 months and 10 at 22 months,were divided to 3 groups.The young control group and senile group were gavaged with saline,while young omeprazole group was gavaged with omeprazole [30 mg/(kg·d)].The pH values were measured after 2 weeks.Bacterial culture of gastric and lung tissue were gained,and pathological sections of stomach and lung were made.We also observed if there were any rats developing diarrhea.Result Compared with the young control group,the gastric pH value,number of gastric and pulmonary bacteria in the senile group did not increase significantly.The number of gastric and pulmonary bacteria of young omeprazole group increased significantly.There was no obviously infiltration of infectious cells in all gastric tissues,nor any rats developing diarrhea.The lung tissue of young control and senile group were similar,with slightly infiltration of lymphocytes.30% of rats in young omeprazole group had slightly heavier pulmonary infection.Conclusion Along with the increase of gastric pH value,the number of gastric and pulmonary bacteria increased in rats.The pulmonary infection was heavier.No obvious gastroenteritis could be observed.Along with the increase of age,neither the bacteria number of gastric and pulmonary changed significantly in rats,nor did the rats develop heavier gastrointestinal and pulmonary infection." @default.
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- W338201272 date "2009-01-01" @default.
- W338201272 modified "2023-09-23" @default.
- W338201272 title "The relationship between gastric acid, gastric bacteria and infection in rats of different ages." @default.
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