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- W338345967 abstract "A common and most important route for the dissemination of neoplastic cells within the body involves invasion and penetration of tumor cells into blood vessels and/or lymphatics (1–3). Following penetration of blood vessels, tumor cells are either carried away passively in the blood stream or remain at the site of vessel invasion where they proliferate and continue to shed emboli into the circulation (4). Tumor cells arrested in the capillary beds of different organs must then invade the endothelial cell lining and its underlying basal lamina in order to escape into the extravascular tissue and find a proper microenvironment where they can establish metastasis (1–3). Electron microscopic studies have shown local dissolution of the subendothelial basement membrane at its region of contact with invading tumor cells (5), thereby suggesting an enzymatic mechanism. Of particular significance are recent studies on the degradation of collagen type IV (6,7), fibronectin (8,9), laminin (10), and sulfated proteoglycans (8,9,11) by metastatic tumor cells because these macromolecules are the predominant structural constituents in basement membranes (8,12,13)." @default.
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- W338345967 date "1983-01-01" @default.
- W338345967 modified "2023-09-23" @default.
- W338345967 title "Interaction of Metastatic and Non-Metastatic Tumor Lines with Aortic Endothelial Cell Monolayer and Their Underlying Basal Lamina" @default.
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- W338345967 doi "https://doi.org/10.1007/978-3-642-69290-1_19" @default.
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