Matches in SemOpenAlex for { <https://semopenalex.org/work/W338691616> ?p ?o ?g. }
- W338691616 endingPage "228" @default.
- W338691616 startingPage "219" @default.
- W338691616 abstract "Survivin, a unique member of the inhibitor of the apoptosis protein (IAP) family, has been suggested to play a crucial role in promoting the cell cycle and mediates mitosis during embryonic development. However, the role of survivin following traumatic brain injury (TBI) in adult neurogenesis and apoptosis in the mouse dentate gyrus (DG) remains only partially understood. We adopted adenovirus-mediated RNA interference (RNAi) as a means of suppressing the expression of survivin and observed its effects on adult regeneration and neurological function in mice after brain injury. The mice were subjected to TBI, and the ipsilateral hippocampus was then examined using reverse transcription polymerase chain reaction (RT-PCR) and Western blotting analyses. Brain slices were stained for 5'-bromo-2'-deoxyuridine (BrdU) and doublecortin (DCX). Our data showed that survivin knockdown inhibits the proliferation and differentiation of neural precursor cells (NPCs) in the DG of the hippocampus soon after TBI. Furthermore, downregulation of survivin results in a significant increase in programmed cell death in the DG, as assessed using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and 4',6-diamidino-2-phenylindole (DAPI) double staining. The Morris water maze (MWM) test was adopted to evaluate neurological function, which confirmed that knockdown of survivin worsened the memory capacity that was already compromised following TBI. Survivin in adult mice brains after TBI can be successfully down-regulated by RNAi, which inhibited adult hippocampal neurogenesis, promoted apoptotic cell death, and resulted in a negative role in the recovery of dysfunction following injury." @default.
- W338691616 created "2016-06-24" @default.
- W338691616 creator A5005348064 @default.
- W338691616 creator A5008453485 @default.
- W338691616 creator A5014417472 @default.
- W338691616 creator A5020809083 @default.
- W338691616 creator A5042025510 @default.
- W338691616 creator A5045214784 @default.
- W338691616 creator A5049352647 @default.
- W338691616 creator A5054866933 @default.
- W338691616 creator A5088795484 @default.
- W338691616 creator A5089555790 @default.
- W338691616 date "2015-08-01" @default.
- W338691616 modified "2023-09-23" @default.
- W338691616 title "Downregulation of survivin regulates adult hippocampal neurogenesis and apoptosis, and inhibits spatial learning and memory following traumatic brain injury" @default.
- W338691616 cites W1965135427 @default.
- W338691616 cites W1968465823 @default.
- W338691616 cites W1972199597 @default.
- W338691616 cites W1982011744 @default.
- W338691616 cites W1983371178 @default.
- W338691616 cites W1985899045 @default.
- W338691616 cites W1986124856 @default.
- W338691616 cites W1994580609 @default.
- W338691616 cites W1995895567 @default.
- W338691616 cites W2006075702 @default.
- W338691616 cites W2008817420 @default.
- W338691616 cites W2016097648 @default.
- W338691616 cites W2025852867 @default.
- W338691616 cites W2028832381 @default.
- W338691616 cites W2030722162 @default.
- W338691616 cites W2037234825 @default.
- W338691616 cites W2040269953 @default.
- W338691616 cites W2042027922 @default.
- W338691616 cites W2044103334 @default.
- W338691616 cites W2044459199 @default.
- W338691616 cites W2045663952 @default.
- W338691616 cites W2048699935 @default.
- W338691616 cites W2049812302 @default.
- W338691616 cites W2050889407 @default.
- W338691616 cites W2055057101 @default.
- W338691616 cites W2065754676 @default.
- W338691616 cites W2074130453 @default.
- W338691616 cites W2074892613 @default.
- W338691616 cites W2076085750 @default.
- W338691616 cites W2084668521 @default.
- W338691616 cites W2085813350 @default.
- W338691616 cites W2085974955 @default.
- W338691616 cites W2094547160 @default.
- W338691616 cites W2103279053 @default.
- W338691616 cites W2112362033 @default.
- W338691616 cites W2117506912 @default.
- W338691616 cites W2127338217 @default.
- W338691616 cites W2135642570 @default.
- W338691616 cites W2150958921 @default.
- W338691616 cites W2152084055 @default.
- W338691616 cites W2164120535 @default.
- W338691616 cites W2417099019 @default.
- W338691616 doi "https://doi.org/10.1016/j.neuroscience.2015.05.025" @default.
- W338691616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25987205" @default.
- W338691616 hasPublicationYear "2015" @default.
- W338691616 type Work @default.
- W338691616 sameAs 338691616 @default.
- W338691616 citedByCount "15" @default.
- W338691616 countsByYear W3386916162016 @default.
- W338691616 countsByYear W3386916162017 @default.
- W338691616 countsByYear W3386916162018 @default.
- W338691616 countsByYear W3386916162019 @default.
- W338691616 countsByYear W3386916162020 @default.
- W338691616 countsByYear W3386916162021 @default.
- W338691616 countsByYear W3386916162022 @default.
- W338691616 countsByYear W3386916162023 @default.
- W338691616 crossrefType "journal-article" @default.
- W338691616 hasAuthorship W338691616A5005348064 @default.
- W338691616 hasAuthorship W338691616A5008453485 @default.
- W338691616 hasAuthorship W338691616A5014417472 @default.
- W338691616 hasAuthorship W338691616A5020809083 @default.
- W338691616 hasAuthorship W338691616A5042025510 @default.
- W338691616 hasAuthorship W338691616A5045214784 @default.
- W338691616 hasAuthorship W338691616A5049352647 @default.
- W338691616 hasAuthorship W338691616A5054866933 @default.
- W338691616 hasAuthorship W338691616A5088795484 @default.
- W338691616 hasAuthorship W338691616A5089555790 @default.
- W338691616 hasConcept C104317684 @default.
- W338691616 hasConcept C127561419 @default.
- W338691616 hasConcept C134018914 @default.
- W338691616 hasConcept C148762608 @default.
- W338691616 hasConcept C173396325 @default.
- W338691616 hasConcept C190283241 @default.
- W338691616 hasConcept C196795494 @default.
- W338691616 hasConcept C2775975398 @default.
- W338691616 hasConcept C2776464000 @default.
- W338691616 hasConcept C2781461022 @default.
- W338691616 hasConcept C44752575 @default.
- W338691616 hasConcept C4746552 @default.
- W338691616 hasConcept C55493867 @default.
- W338691616 hasConcept C86803240 @default.
- W338691616 hasConcept C95444343 @default.
- W338691616 hasConceptScore W338691616C104317684 @default.