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- W338987964 abstract "Objective To evaluate the in vitro effects of combinatorial drugs of rifampicin,isoniazid,streptomycin and ethambutol against multidrug-resistant Mycobacterium tuberculosis(MDR-TB) strains,and further discuss the efficacy of chemotherapy by using combinatorial drugs to treat multidrug-resistance tuberculosis clinically.Methods Clinical isolated Mycobacterium tuberculosis(MTB) strains were cultured on Lowenstein-Jensen(L-J) medium.Then 10 MDR-TB strains were screened and cultured by MTB/BacT ALERT 3D system.The in vitro effects of combinatorial drugs or each drug respectively on MDR-TB strains or H37Rv strain were evaluated by MIC(minimum inhibitory concentration) and Cmax in blood.To further test the bacteria-killing effects of these drugs,suspension of 3D negative culture was transferred to L-J medium after 42 days.Results The outcomes of single drug treatment in 3D system were consistent with the outcomes in L-J medium.Combinatorial drugs treated MDR-TB strains remained longer as MIC and Cmax negative in 3D system.However,further cultivation in L-J medium after transferring turned back to positive.Case report indicated that those 10 strains were all from re-examined patients who failed the regular chemotherapy.Conclusion This small-sample experiment indicates that combinatorial drugs are able to inhibit MDR-TB strains(MIC and Cmax),but have no killing effects in a synergistic way.This is consistent with the clinical outcomes of TB patient treatment." @default.
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- W338987964 date "2009-01-01" @default.
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- W338987964 title "In vitro effects of combinatorial drugs against multidrug-resistant mycobacterium tuberculosis." @default.
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