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- W339506736 endingPage "128" @default.
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- W339506736 abstract "Protein homeostasis is a critical cellular process to maintain protein function. Because the genome encodes for a very large number of discrete proteins and only a fraction of this number are needed or utilized for cellular function at a given time, a closely regulated system is necessary to control the synthesis, transport, and degradation of these molecules. The turnover of proteins can vary and cells tend to accumulate a large amount of expended, sometimes aberrantly folded and oxidized proteins that must be eliminated, degraded, and/or recycled. The majority of eukaryotic protein degradation is executed by the ubiquitin proteasome system (UPS). This system has acquired a central position in our understanding of cellular protein homeostasis. The UPS is one of the many posttranslational modifications of proteins that include acylation, alkylation, glycosylation, hydroxylation, and nitrosylation. These posttranslational modifications, while essential for protein homeostasis, if perturbed sufficiently, can also lead to pathological change. Abnormalities of the UPS have been implicated in the pathogenesis of a variety of diseases including cardiovascular disease. Accumulating evidence in recent years has strongly implicated the UPS in cardiovascular physiology and pathology. This chapter will review the role of the UPS in cardiovascular pathophysiology. We will describe the basic mechanistic underpinnings of the UPS and delineate its role in vascular physiology. The potential waypoints in the UPS signaling system where pathological events are known or thought to occur will be defined. Finally, an overview of how the UPS can be pharmacologically manipulated and whether this strategy has therapeutic currency will be presented." @default.
- W339506736 created "2016-06-24" @default.
- W339506736 creator A5054097165 @default.
- W339506736 creator A5084679129 @default.
- W339506736 date "2012-01-01" @default.
- W339506736 modified "2023-09-26" @default.
- W339506736 title "The Ubiquitin Proteasome System in Endothelial Cell Dysfunction and Vascular Disease" @default.
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