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- W339731125 abstract "An incipient phase of supernormal glomerular filtration rate (GFR) often heralds diabetic kidney disease (DKD) and many other chronic nephropathies. We review the various definitions set for glomerular hyperfiltration (GH) and the concept of renal functional response induced by haemodynamic and/or metabolic stimuli. The clinical applications and limitations for testing of this response are alluded to. The causes of GH are discussed as perturbations of the physiologic mechanisms that control GFR, emphasizing the unique location of the glomerulus between two sets of resistant arterioles. DKD is discussed as a standard example for the role of GH in initiation and progression of the renal insult. The differences between physiologic and pathologic GH are explored and the morbid consequences of persistent GH are explained. GH is an early pathogenetic alteration in a divergent spectrum of renal disorders whose timely recognition and management might help retard occurrence and progression of chronic kidney diseases.Keywords: Glomerular filtration rate, glomerular hyperfiltration, renal functional reserve, renal plasma flow, chronic kidney diseas" @default.
- W339731125 created "2016-06-24" @default.
- W339731125 creator A5037949238 @default.
- W339731125 date "1919-05-01" @default.
- W339731125 modified "2023-09-26" @default.
- W339731125 title "Developmental Phases of the Protozoon of Blackhead in Turkeys." @default.
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