FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W33984518> ?p ?o ?g. }

• W33984518 endingPage "503" @default.
• W33984518 startingPage "479" @default.
• W33984518 abstract "Effective antitumor immunity requires the generation and persistence of functional tumor-specific T-cell responses. Among the critical factors that often control these responses is how the antigen is delivered and presented to T cells. The use of peptide-based vaccination has been found to be a promising means to induce antitumor T-cell responses but with limited effects even if the peptide is co-delivered with a potent adjuvant. This limited response could be due to cancer-induced dysfunction in dendritic cells (DC), which play a central role in shaping the quantity and quality of antitumor immunity. Therefore, DC-based peptide delivery of tumor antigen is becoming a potential approach in cancer immunotherapy. In this approach, autologous DC are generated from their precursors in bone marrow or peripheral blood mononuclear cells, loaded with tumor antigen(s) and then infused back to the tumor-bearing host in about 7 days. This DC-based vaccination can act as an antigen delivery vehicle as well as a potent adjuvant, resulting in measurable antitumor immunity in several cancer settings in preclinical and clinical studies. This chapter focuses on DC-based vaccination and how this approach can be more efficacious in cancer immunotherapy.Effective antitumor immunity requires the generation and persistence of functional tumor-specific T-cell responses. Among the critical factors that often control these responses is how the antigen is delivered and presented to T cells. The use of peptide-based vaccination has been found to be a promising means to induce antitumor T-cell responses but with limited effects even if the peptide is co-delivered with a potent adjuvant. This limited response could be due to cancer-induced dysfunction in dendritic cells (DC), which play a central role in shaping the quantity and quality of antitumor immunity. Therefore, DC-based peptide delivery of tumor antigen is becoming a potential approach in cancer immunotherapy. In this approach, autologous DC are generated from their precursors in bone marrow or peripheral blood mononuclear cells, loaded with tumor antigen(s) and then infused back to the tumor-bearing host in about 7 days. This DC-based vaccination can act as an antigen delivery vehicle as well as a potent adjuvant, resulting in measurable antitumor immunity in several cancer settings in preclinical and clinical studies. This chapter focuses on DC-based vaccination and how this approach can be more efficacious in cancer immunotherapy." @default.
• W33984518 created "2016-06-24" @default.
• W33984518 creator A5018009812 @default.
• W33984518 date "2014-01-01" @default.
• W33984518 modified "2023-10-16" @default.
• W33984518 title "The Use of Dendritic Cells for Peptide-Based Vaccination in Cancer Immunotherapy" @default.
• W33984518 cites W1492494580 @default.
• W33984518 cites W1501513289 @default.
• W33984518 cites W1506811134 @default.
• W33984518 cites W1510006570 @default.
• W33984518 cites W1521418395 @default.
• W33984518 cites W1547817524 @default.
• W33984518 cites W1597092954 @default.
• W33984518 cites W1600921312 @default.
• W33984518 cites W1655423342 @default.
• W33984518 cites W1661544713 @default.
• W33984518 cites W1879131976 @default.
• W33984518 cites W1895527819 @default.
• W33984518 cites W1924612354 @default.
• W33984518 cites W1934655176 @default.
• W33984518 cites W1963605882 @default.
• W33984518 cites W1966233007 @default.
• W33984518 cites W1968619878 @default.
• W33984518 cites W1969146914 @default.
• W33984518 cites W1969238175 @default.
• W33984518 cites W1970555729 @default.
• W33984518 cites W1972107031 @default.
• W33984518 cites W1973917219 @default.
• W33984518 cites W1977732271 @default.
• W33984518 cites W1978650534 @default.
• W33984518 cites W1979680810 @default.
• W33984518 cites W1980241157 @default.
• W33984518 cites W1981087308 @default.
• W33984518 cites W1983673827 @default.
• W33984518 cites W1987446429 @default.
• W33984518 cites W1987834338 @default.
• W33984518 cites W1989574516 @default.
• W33984518 cites W1990459651 @default.
• W33984518 cites W1993781791 @default.
• W33984518 cites W1993998017 @default.
• W33984518 cites W1999729166 @default.
• W33984518 cites W2000154274 @default.
• W33984518 cites W2000286082 @default.
• W33984518 cites W2001740055 @default.
• W33984518 cites W2002918113 @default.
• W33984518 cites W2004150448 @default.
• W33984518 cites W2004708987 @default.
• W33984518 cites W2006733833 @default.
• W33984518 cites W2010120404 @default.
• W33984518 cites W2013305758 @default.
• W33984518 cites W2017549500 @default.
• W33984518 cites W2019546595 @default.
• W33984518 cites W2020507197 @default.
• W33984518 cites W2021021710 @default.
• W33984518 cites W2021268612 @default.
• W33984518 cites W2022771612 @default.
• W33984518 cites W2023218072 @default.
• W33984518 cites W2024167344 @default.
• W33984518 cites W2025482003 @default.
• W33984518 cites W2027804050 @default.
• W33984518 cites W2028092080 @default.
• W33984518 cites W2031745114 @default.
• W33984518 cites W2032655351 @default.
• W33984518 cites W2032967122 @default.
• W33984518 cites W2035523654 @default.
• W33984518 cites W2037819715 @default.
• W33984518 cites W2038918212 @default.
• W33984518 cites W2041288370 @default.
• W33984518 cites W2042373608 @default.
• W33984518 cites W2043875007 @default.
• W33984518 cites W2044399538 @default.
• W33984518 cites W2047392100 @default.
• W33984518 cites W2048076679 @default.
• W33984518 cites W2049332097 @default.
• W33984518 cites W2050633051 @default.
• W33984518 cites W2052065441 @default.
• W33984518 cites W2052147215 @default.
• W33984518 cites W2053829861 @default.
• W33984518 cites W2054402331 @default.
• W33984518 cites W2054450974 @default.
• W33984518 cites W2057790734 @default.
• W33984518 cites W2059588067 @default.
• W33984518 cites W2060076339 @default.
• W33984518 cites W2060473602 @default.
• W33984518 cites W2061176964 @default.
• W33984518 cites W2061824209 @default.
• W33984518 cites W2066146382 @default.
• W33984518 cites W2066857894 @default.
• W33984518 cites W2068323100 @default.
• W33984518 cites W2069486064 @default.
• W33984518 cites W2074900897 @default.
• W33984518 cites W2080073071 @default.
• W33984518 cites W2081027784 @default.
• W33984518 cites W2084692958 @default.
• W33984518 cites W2085588982 @default.
• W33984518 cites W2088091610 @default.
• W33984518 cites W2089567851 @default.
• W33984518 cites W2097829667 @default.

• next