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- W339898101 abstract "Fourier transform P-31 NMR spectroscopy (81 MHz) was used to investigate the biochemical nature of insulin action upon the cell wall-deficient slime mutant of Neurospora crassa. Spectra of oxygenated, living cells (ca.10/sup 9//ml.) in late logarithmic-early stationary phase of growth were accumulated for approximately 20 min. (350-450 pulses). Pronounced differences were seen in the metabolite levels of cells cultured for 18-21 hours in the presence of insulin (100 nM) as compared to cells cultured in its absence. Differences in the insulin-grown cells included higher levels of sugar phosphates, inorganic (cytoplasmic) phosphate, NAD+/NADH and UDP-glucose (UDPG) compared to control cells, in which UDP-N-acetylglucosamine (UDPNAG) was the prominent sugar nucleotide. When 100 mM glucose was administered with insulin immediately prior to measurement, short term effects were seen. There were significant increases of sugar phosphates, inorganic phosphate, NAD+/NADH, phosphodiesters and UDPG relative to the case of glucose addition alone. These results are wholly consistent with the known influence of insulin upon mammalian metabolism: stimulation of glucose uptake, phosphorylation and oxidation, phosphatide synthesis and Pi uptake." @default.
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- W339898101 date "1986-05-01" @default.
- W339898101 modified "2023-09-27" @default.
- W339898101 title "Actions of mammalian insulin on a Neurospora variant: effects on intracellular metabolite levels as monitored by P-31 NMR spectroscopy" @default.
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