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- W33990412 abstract "Bronchiolitis obliterans organizing pneumonia (BOOP) is clinically and histologically difficult to differentiate from chronic eosinophilic pneumonia (CEP). The common histo-logical feature of these diseases is an infiltration of mononu-clear cells into the small airway, interstitial tissue and alveoli. Activation of T cells and secretion of lymphokines play a crucial role in the regulation and coordination of immune responses and inflammatory processes. In this study, we demonstrated the distribution of lymphocyte subpopulations and their stage of activation and T cell-derived cytokine, IL-5 level in bronchoalveolar lavage (BAL) fluid obtained from patients with BOOP and CEP by com-parison with sarcoidosis and diffuse panbronchiolitis (DPB). Flow cytometric analysis of T cell activation mark-ers revealed that BOOP and sarcoidosis are characterized by increased absolute numbers of HLA-DR-bearing T cell subsets, while the relative numbers were increased in CEP and DPB. IL-5 in BAL fluids from BOOP and CEP was significantly high levels, and CEP patients with the high level of IL-5 showed the marked elevation of BAL eosinophils. Furthermor, it is of interest that the absolute numbers of HLA-DR T cells correlated with IL-5 levels in BAL fluid. These results suggest that activated T cells and secretion of IL-5 may be important factors in the pathogenetic processes of BOOP and CEP." @default.
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- W33990412 date "1994-12-15" @default.
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- W33990412 title "Interleukin 5 Levels in Bronchoalveolar Lavage Fluid from Patients with Interstitial Lung Disease" @default.
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