Matches in SemOpenAlex for { <https://semopenalex.org/work/W339936374> ?p ?o ?g. }
- W339936374 endingPage "110" @default.
- W339936374 startingPage "100" @default.
- W339936374 abstract "Nanocarriers are widely used for delivering drugs to tumors and are progressing in a stable trend. The enhanced permeability and retention (EPR) effect has been a key rationale for the development of stimulus-responsive nanocarriers to solid tumor. In this study, we developed a kind of novel nanocarrier, G-AuNPs-DOX-PEG, which was constructed with shrinkable gelatin nanoparticles coated, doxorubicin (DOX) tethered gold nanoparticles and long chain polyethylene glycol (PEG). The particle size of G-AuNPs-DOX-PEG was 186.5 nm with a zeta potential of -4.21 mV and the DOX loading capacity was 9.22%. In vitro, the G-AuNPs-DOX-PEG could be degraded by MMP-2 proteins with a size shrink from 186.5 nm to 59.3 nm. The release of DOX from G-AuNPs-DOX-PEG was in a pH- and time-dependent manner. At pH 5.0, the release of DOX was much quicker than that at high pH value and the cumulative release rate of DOX from G-AuNPs-DOX-PEG was approach 90.9%. Cellular uptake demonstrated that G-AuNPs-DOX-PEG could be internalized via the endosome-mediated pathway. Tumor spheroid penetration and collagen gel diffusion showed G-AuNPs-DOX-PEG with pre-incubation with MMP-2 could significantly enhance its penetrating efficiency. In vivo and ex vivo imaging exhibit that G-AuNPs-DOX-PEG could distribute into 4T1 and B16F10 tumor at a highest intensity. Correspondingly, 4T1 and B16F10 tumor bearing mice treated with G-AuNPs-DOX-PEG displayed the lowest tumor growth rate. In summary, the tumor microenvironment sensitive size-shrinkable G-AuNPs-DOX-PEG could deliver into deep tumor region and then release DOX, resulting in a best anti-tumor effect." @default.
- W339936374 created "2016-06-24" @default.
- W339936374 creator A5004069380 @default.
- W339936374 creator A5006855927 @default.
- W339936374 creator A5012475082 @default.
- W339936374 creator A5026174200 @default.
- W339936374 creator A5040377010 @default.
- W339936374 creator A5046020427 @default.
- W339936374 creator A5048643609 @default.
- W339936374 creator A5057126225 @default.
- W339936374 creator A5065789169 @default.
- W339936374 date "2015-08-01" @default.
- W339936374 modified "2023-10-01" @default.
- W339936374 title "Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release" @default.
- W339936374 cites W1968583232 @default.
- W339936374 cites W1976041621 @default.
- W339936374 cites W1976947090 @default.
- W339936374 cites W1985858988 @default.
- W339936374 cites W1990983926 @default.
- W339936374 cites W1992560794 @default.
- W339936374 cites W1996993122 @default.
- W339936374 cites W2005840555 @default.
- W339936374 cites W2006202974 @default.
- W339936374 cites W2019410828 @default.
- W339936374 cites W2025036947 @default.
- W339936374 cites W2035252444 @default.
- W339936374 cites W2038449477 @default.
- W339936374 cites W2045872960 @default.
- W339936374 cites W2062252988 @default.
- W339936374 cites W2074011353 @default.
- W339936374 cites W2076855170 @default.
- W339936374 cites W2083710155 @default.
- W339936374 cites W2097091783 @default.
- W339936374 cites W2097857976 @default.
- W339936374 cites W2098054841 @default.
- W339936374 cites W2121421529 @default.
- W339936374 cites W2132732108 @default.
- W339936374 cites W2141518860 @default.
- W339936374 cites W2141638844 @default.
- W339936374 cites W2153771870 @default.
- W339936374 cites W2167798860 @default.
- W339936374 cites W2323101083 @default.
- W339936374 cites W2324209741 @default.
- W339936374 cites W2327770163 @default.
- W339936374 cites W2330461172 @default.
- W339936374 doi "https://doi.org/10.1016/j.biomaterials.2015.05.006" @default.
- W339936374 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25988725" @default.
- W339936374 hasPublicationYear "2015" @default.
- W339936374 type Work @default.
- W339936374 sameAs 339936374 @default.
- W339936374 citedByCount "234" @default.
- W339936374 countsByYear W3399363742015 @default.
- W339936374 countsByYear W3399363742016 @default.
- W339936374 countsByYear W3399363742017 @default.
- W339936374 countsByYear W3399363742018 @default.
- W339936374 countsByYear W3399363742019 @default.
- W339936374 countsByYear W3399363742020 @default.
- W339936374 countsByYear W3399363742021 @default.
- W339936374 countsByYear W3399363742022 @default.
- W339936374 countsByYear W3399363742023 @default.
- W339936374 crossrefType "journal-article" @default.
- W339936374 hasAuthorship W339936374A5004069380 @default.
- W339936374 hasAuthorship W339936374A5006855927 @default.
- W339936374 hasAuthorship W339936374A5012475082 @default.
- W339936374 hasAuthorship W339936374A5026174200 @default.
- W339936374 hasAuthorship W339936374A5040377010 @default.
- W339936374 hasAuthorship W339936374A5046020427 @default.
- W339936374 hasAuthorship W339936374A5048643609 @default.
- W339936374 hasAuthorship W339936374A5057126225 @default.
- W339936374 hasAuthorship W339936374A5065789169 @default.
- W339936374 hasConcept C10138342 @default.
- W339936374 hasConcept C104819515 @default.
- W339936374 hasConcept C12554922 @default.
- W339936374 hasConcept C141071460 @default.
- W339936374 hasConcept C150903083 @default.
- W339936374 hasConcept C155672457 @default.
- W339936374 hasConcept C162324750 @default.
- W339936374 hasConcept C171250308 @default.
- W339936374 hasConcept C18150654 @default.
- W339936374 hasConcept C185592680 @default.
- W339936374 hasConcept C192562407 @default.
- W339936374 hasConcept C207001950 @default.
- W339936374 hasConcept C2776694085 @default.
- W339936374 hasConcept C2776964284 @default.
- W339936374 hasConcept C2781303535 @default.
- W339936374 hasConcept C2909829705 @default.
- W339936374 hasConcept C54400483 @default.
- W339936374 hasConcept C55493867 @default.
- W339936374 hasConcept C71924100 @default.
- W339936374 hasConcept C86803240 @default.
- W339936374 hasConceptScore W339936374C10138342 @default.
- W339936374 hasConceptScore W339936374C104819515 @default.
- W339936374 hasConceptScore W339936374C12554922 @default.
- W339936374 hasConceptScore W339936374C141071460 @default.
- W339936374 hasConceptScore W339936374C150903083 @default.
- W339936374 hasConceptScore W339936374C155672457 @default.
- W339936374 hasConceptScore W339936374C162324750 @default.
- W339936374 hasConceptScore W339936374C171250308 @default.