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- W340285462 abstract "Expression of CCR7 receptor on tumor cells membrane correlates withlymph node metastases in many human cancers and evidence suggests thattumor cells which also secrete CCR7-ligands can drive their own chemotaxistowards lymphatic guided by fluid flow from the tumor to draining lymphatic.Autocrine signals and paracrine signals from lymphatic endothelial cells bothguide tumor cells chemotaxis and relative contributions were modeledcomputationally by Shields and Fleury for a single tumor cell. This model wasfurther developed to assess how a growing tumor could detect autocrine vsparacrine signal and predicted that when the tumor mass gets bigger paracrinesignal loses relevance.To verify this experimentally, we developed a physiologically relevantassay to quantify migration of different tumor cell densities and to show thatindeed the lymphatic endothelial signal becomes of less importance when celldensity increases.In the second part of our study we consider the role of the enzymeIndoleamine 2,3 dioxygenase (IDO) as one molecular mechanism thatcontributes to tumor induced tolerance.There have been many reported mechanisms explaining that, byattracting immune cells, a tumor can control the immune response. From all theimmunosuppressive networks taking place, we have chosen to explore the roleof IDO+ DCs in the tumor environment." @default.
- W340285462 created "2016-06-24" @default.
- W340285462 creator A5050169131 @default.
- W340285462 date "2008-01-01" @default.
- W340285462 modified "2023-09-27" @default.
- W340285462 title "Lymphoid chemockine secretion by B16 melanoma cancer cells and it effects on communication with lymphatics and the immune systhem" @default.
- W340285462 hasPublicationYear "2008" @default.
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