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- W340552615 abstract "Objective:To observetheexpressionof humanleukocyticantigenDR(HLA-DR)inprimaryhepatocellular carcinoma(HCC)anditsup-regulationby interferon(IFN).Methods:The expressionof HLA-DRin46specimensof humanHCCtissues,4humanHCCcelllines(SMMC-7721,HCC-9204,BEL-7402andHHCC)anda humanhepatocyte celllineQZGwas respectivelydetectedby immunohistochemicalABCstainingandflowcytometry.Theexpressionof HLA-DRinthe5celllineswasdetectedby ELISAbeforeandafterthecellsweretreatedwithIFN-γor IFN-α.Results:Eighteenoutof46HCCtissues(39.1%)expressedHLA-DR,whereasallthenormallivertissuesimmediatelyadjacentto HCCtissueswereHLA-DR-negative.No obviousHLA-DR-positivestainingwas foundin allthe5celllines.The expressionof HLA-DRwas up-regulatedin allthe5celllinesafterIFN-γor IFN-αtreatment.The up-regulationof HLA-DRinQZGcellswaslessobviousthanthatinHCCcelllines.Theeffectof IFN-γwasmoresignificantthanthatof IFN-α.Conclusion:HCCtissuescanexpressHLA-DRto someextent,butHCCcelllinesdo notexpressdetectable HLA-DR.IFNcanup-regulateHLA-DRexpressioninHCCcells." @default.
- W340552615 created "2016-06-24" @default.
- W340552615 creator A5088330794 @default.
- W340552615 date "2001-01-01" @default.
- W340552615 modified "2023-09-25" @default.
- W340552615 title "Expression of HLA-DR antigen in hepatocellular carcinoma and its up-regulation by interferon" @default.
- W340552615 hasPublicationYear "2001" @default.
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