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• W340778051 abstract "miR-21 shares a potential oncogenic function. The overexpression of miR-21 was common in glioblastoma, which is the most common lethal primary intracranial tumor. The study aimed at miR-21 effect on Glioblastoma cell line A172 of proliferation, apoptosis, and chemosensitivity and its definite mechanism of target gene FOXO1. Effect and mechanism were evaluated by colony forming cell assay, annexin V-FITC/PI apoptosis assay, TUNEL apoptosis assay, luciferase-reporter activities assay, RNA interference, western-blot and Real-Time PCR. The statistics revealed miR-21 promoted A172 cell proliferation and suppressed the chemosensitivity, and also showed that miR-21 could bind with FOXO1 mRNA and prevent FOXO1 translation via its 3'UTR to regulate the function. These findings suggest that miR-21 plays an important role in cell proliferation and chemosensitivity by inhibiting FOXO1, and show much more significance for exploring miR-21 inhibitor in A172 therapy." @default.
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• W340778051 date "2014-01-01" @default.
• W340778051 modified "2023-10-11" @default.
• W340778051 title "miR-21 induces cell proliferation and suppresses the chemosensitivity in glioblastoma cells via downregulation of FOXO1." @default.
• W340778051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4161547" @default.
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