Matches in SemOpenAlex for { <https://semopenalex.org/work/W340957314> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W340957314 abstract "Abstract The viral biosynthesis of a simian adenovirus, SV15, was studied in both simian and nonsimian cells. In rhesus monkey kidney cells, viral complement-fixing (CF) antigen and infectious progeny virus were first detected 12 hours after virus inoculation. Synthesis of viral DNA was initiated at about 5–6 hours before the first appearance of complete virus; viral protein was first obtained 2–3 hours before the maturation of virus. In primary hamster kidney cells, SV15 induced an abortive infection. DNA synthesis was stimulated in SV15-infected hamster kidney cells as determined by the increased uptake of thymidine- 3 H, but viral antigen could not be detected by CF test, immunofluorescence or agar gel double-diffusion methods. At no time could progeny infectious virus be detected by infectivity titrations. The use of polyoma virus or SV40 as a “helper” virus did not induce the production of SV15 infectious virus in hamster kidney cells. Fluorouracil and cytosine arabinoside were unable to inhibit cytopathic effect as well as the formation of eosinophilic inclusions in SV15-infected RhMK or HamK cells; these inhibitors did prevent the development of basophilic inclusions in infected RhMK cells. Actinomycin D and streptovitacin A inhibited cellular changes and eosinophilic inclusions induced by SV15 in both cell systems tested. In monkey cells, fluorouracil at concentrations of 12–50 μg/ml inhibited 90% or more of the infectious virus, whereas only a 50% reduction of complement-fixing antigen occurred at concentrations of 25–50 μg/ml. To obtain a greater than 90% reduction of CF antigen production, 100 μg/ml of FU was required. Cytosine arabinoside (10 μg/ml), actinomycin D (1 μg/ml), and streptovitacin A (3 μg/ml) completely inhibited viral antigen as well as infectious virus production." @default.
- W340957314 created "2016-06-24" @default.
- W340957314 creator A5010244930 @default.
- W340957314 creator A5022526442 @default.
- W340957314 creator A5044140493 @default.
- W340957314 date "1968-06-01" @default.
- W340957314 modified "2023-09-26" @default.
- W340957314 title "Productive and abortive infections of simian and nonsimian cells with a simian adenovirus SV15" @default.
- W340957314 cites W1494248456 @default.
- W340957314 cites W1508252079 @default.
- W340957314 cites W1540428970 @default.
- W340957314 cites W1549600661 @default.
- W340957314 cites W1592085001 @default.
- W340957314 cites W2002335863 @default.
- W340957314 cites W2059750927 @default.
- W340957314 cites W2119513790 @default.
- W340957314 cites W2150685305 @default.
- W340957314 cites W2415422935 @default.
- W340957314 doi "https://doi.org/10.1016/0042-6822(68)90271-7" @default.
- W340957314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4298713" @default.
- W340957314 hasPublicationYear "1968" @default.
- W340957314 type Work @default.
- W340957314 sameAs 340957314 @default.
- W340957314 citedByCount "6" @default.
- W340957314 crossrefType "journal-article" @default.
- W340957314 hasAuthorship W340957314A5010244930 @default.
- W340957314 hasAuthorship W340957314A5022526442 @default.
- W340957314 hasAuthorship W340957314A5044140493 @default.
- W340957314 hasConcept C147483822 @default.
- W340957314 hasConcept C153911025 @default.
- W340957314 hasConcept C159047783 @default.
- W340957314 hasConcept C203014093 @default.
- W340957314 hasConcept C2522874641 @default.
- W340957314 hasConcept C2778575167 @default.
- W340957314 hasConcept C33263850 @default.
- W340957314 hasConcept C54355233 @default.
- W340957314 hasConcept C81885089 @default.
- W340957314 hasConcept C86803240 @default.
- W340957314 hasConceptScore W340957314C147483822 @default.
- W340957314 hasConceptScore W340957314C153911025 @default.
- W340957314 hasConceptScore W340957314C159047783 @default.
- W340957314 hasConceptScore W340957314C203014093 @default.
- W340957314 hasConceptScore W340957314C2522874641 @default.
- W340957314 hasConceptScore W340957314C2778575167 @default.
- W340957314 hasConceptScore W340957314C33263850 @default.
- W340957314 hasConceptScore W340957314C54355233 @default.
- W340957314 hasConceptScore W340957314C81885089 @default.
- W340957314 hasConceptScore W340957314C86803240 @default.
- W340957314 hasLocation W3409573141 @default.
- W340957314 hasLocation W3409573142 @default.
- W340957314 hasOpenAccess W340957314 @default.
- W340957314 hasPrimaryLocation W3409573141 @default.
- W340957314 hasRelatedWork W1487857142 @default.
- W340957314 hasRelatedWork W1637353982 @default.
- W340957314 hasRelatedWork W1702322095 @default.
- W340957314 hasRelatedWork W1865764402 @default.
- W340957314 hasRelatedWork W1968481341 @default.
- W340957314 hasRelatedWork W1975114493 @default.
- W340957314 hasRelatedWork W2102122748 @default.
- W340957314 hasRelatedWork W2126983899 @default.
- W340957314 hasRelatedWork W2186972692 @default.
- W340957314 hasRelatedWork W2401150902 @default.
- W340957314 isParatext "false" @default.
- W340957314 isRetracted "false" @default.
- W340957314 magId "340957314" @default.
- W340957314 workType "article" @default.