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- W341252017 abstract "This chapter presents a study aiming to identify the minimal doses that produce clinical locoism and better describe the lesions of locoweed (Astragalus mollissimus/Oxytropis sericea) poisoning in horses. Sixteen mature mares were randomly divided into 4 groups of 4 animals. The horses were individually penned and fed a mixed locoweed ration twice a day to obtain swainsonine doses of 0.0, 0.2, 0.6 and 1.8 mg swainsonine per kg body weight per day. All groups were fed for 45 days. Within 10 days of treatment, the mares from the 0.6 and 1.8 mg groups were depressed and took longer to ingest their ration. These animals were hesitant to move and had subtle intention tremors when moving. These clinical signs became more severe and after 45 days, 5 of the 6 mares had abnormal oestrus cycles. When the ovaries were biopsied from this group, several were cystic. After 60 days of treatment, the 0.2 mg/kg group also became depressed and started to lose weight. The clinical condition of the animals in the higher dose groups continued to deteriorate. Two animals became anorexic and dangerous to handle and these animals were euthanized and necropsied early. At necropsy, the treated animals were thin with lack of visceral and subcutaneous adipose tissue. Histologically, the 0.6 and 1.8 mg swainsonine groups all had severe vacuolation of nearly all neuronal and visceral tissues. The 0.2 mg swainsonine group had mild vacuolation of the Purkinje cells and renal tubular cells. The mares that were allowed to recover began to have normal oestrus cycles and near the end of the recovery period began to eat better and gain weight. Histologically, these animals had some neuronal vacuolation with loss of neurons and axonal dystrophy (spheroids)." @default.
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- W341252017 date "2011-01-01" @default.
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- W341252017 title "The comparative pathology of locoweed poisoning in horses and other livestock." @default.
- W341252017 doi "https://doi.org/10.1079/9781845938338.0309" @default.
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