FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3412872> ?p ?o ?g. }

• W3412872 endingPage "295" @default.
• W3412872 startingPage "290" @default.
• W3412872 abstract "Procalcitonin (PCT) is one of the precursors in the synthesis of calcitonin in thyroidal C-cells and other neuroendocrine cells. PCT, among other calcitonin precursors, is elevated in the serum of many conditions associated with a systemic inflammatory response syndrome, even in the absence of the thyroid gland. The aim of our study was to identify PCT-producing extrathyroidal tissues in primate sepsis. In order to induce PCT production, we treated four olive baboons (papio cynocephalus anubis) with the endotoxin lipopolysaccharide (LPS) from s. typhimurium. We found an increase in serum PCT 3 to 5 hours after LPS injection to levels of 0.2 ng/ml, attaining a peak above 4 ng/ml PCT at 10 hours. In contrast, the untreated baboon had no detectable circulating PCT in the serum. In one animal, additional LPS boosting after 24 hours did not increase serum PCT further. Soluble proteins were extracted from different organs, fractionated by C18 extraction, and PCT was measured in an immunoluminometric assay (ILMA), which was specifically developed for this study. PCT concentrations above 0.2 ng/g of wet tissue were found in a variety of organs in LPS treated baboons, but not in the control baboon. Organs and tissues with the highest PCT concentration included liver, kidney, aorta, fat, ovaries, bladder and adrenal gland. RT-PCR confirmed an extrathyroidal origin of PCT. Importantly, CT-mRNA expression was found in liver, lung, kidney, adrenal, colon, skin, spleen, brain and pancreas. In conclusion, our data confirm previous findings in hamsters, indicating an extrathyroidal origin for PCT in sepsis. Our primate model offers a valuable tool for further investigation of PCT's pathophysiological role and its immunoneutralization as a therapy for sepsis." @default.
• W3412872 created "2016-06-24" @default.
• W3412872 creator A5015846826 @default.
• W3412872 creator A5029542553 @default.
• W3412872 creator A5034814445 @default.
• W3412872 creator A5036583068 @default.
• W3412872 creator A5036806632 @default.
• W3412872 creator A5053696525 @default.
• W3412872 creator A5057951246 @default.
• W3412872 creator A5068855053 @default.
• W3412872 creator A5073902878 @default.
• W3412872 date "2003-05-01" @default.
• W3412872 modified "2023-09-30" @default.
• W3412872 title "Production of Procalcitonin (PCT) in Non-Thyroidal Tissue after LPS Injection" @default.
• W3412872 cites W1897448630 @default.
• W3412872 cites W1969534289 @default.
• W3412872 cites W1984666117 @default.
• W3412872 cites W1989816492 @default.
• W3412872 cites W1994362071 @default.
• W3412872 cites W1996147623 @default.
• W3412872 cites W2004556024 @default.
• W3412872 cites W2012602614 @default.
• W3412872 cites W2018407610 @default.
• W3412872 cites W2020153124 @default.
• W3412872 cites W2044142824 @default.
• W3412872 cites W2045097215 @default.
• W3412872 cites W2054632804 @default.
• W3412872 cites W2081046221 @default.
• W3412872 cites W2084662390 @default.
• W3412872 cites W2085544415 @default.
• W3412872 cites W2087723235 @default.
• W3412872 cites W2100504222 @default.
• W3412872 cites W2128822376 @default.
• W3412872 cites W2137298398 @default.
• W3412872 cites W2158730983 @default.
• W3412872 cites W2162824139 @default.
• W3412872 cites W2462143292 @default.
• W3412872 cites W2766488114 @default.
• W3412872 doi "https://doi.org/10.1055/s-2003-41304" @default.
• W3412872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12915998" @default.
• W3412872 hasPublicationYear "2003" @default.
• W3412872 type Work @default.
• W3412872 sameAs 3412872 @default.
• W3412872 citedByCount "94" @default.
• W3412872 countsByYear W34128722012 @default.
• W3412872 countsByYear W34128722013 @default.
• W3412872 countsByYear W34128722014 @default.
• W3412872 countsByYear W34128722015 @default.
• W3412872 countsByYear W34128722016 @default.
• W3412872 countsByYear W34128722017 @default.
• W3412872 countsByYear W34128722018 @default.
• W3412872 countsByYear W34128722019 @default.
• W3412872 countsByYear W34128722020 @default.
• W3412872 countsByYear W34128722021 @default.
• W3412872 countsByYear W34128722022 @default.
• W3412872 countsByYear W34128722023 @default.
• W3412872 crossrefType "journal-article" @default.
• W3412872 hasAuthorship W3412872A5015846826 @default.
• W3412872 hasAuthorship W3412872A5029542553 @default.
• W3412872 hasAuthorship W3412872A5034814445 @default.
• W3412872 hasAuthorship W3412872A5036583068 @default.
• W3412872 hasAuthorship W3412872A5036806632 @default.
• W3412872 hasAuthorship W3412872A5053696525 @default.
• W3412872 hasAuthorship W3412872A5057951246 @default.
• W3412872 hasAuthorship W3412872A5068855053 @default.
• W3412872 hasAuthorship W3412872A5073902878 @default.
• W3412872 hasConcept C10936531 @default.
• W3412872 hasConcept C126322002 @default.
• W3412872 hasConcept C134018914 @default.
• W3412872 hasConcept C2777714996 @default.
• W3412872 hasConcept C2778384902 @default.
• W3412872 hasConcept C2778754761 @default.
• W3412872 hasConcept C2779594886 @default.
• W3412872 hasConcept C2779627488 @default.
• W3412872 hasConcept C2780091579 @default.
• W3412872 hasConcept C2780694816 @default.
• W3412872 hasConcept C2780931953 @default.
• W3412872 hasConcept C526584372 @default.
• W3412872 hasConcept C71924100 @default.
• W3412872 hasConcept C86803240 @default.
• W3412872 hasConceptScore W3412872C10936531 @default.
• W3412872 hasConceptScore W3412872C126322002 @default.
• W3412872 hasConceptScore W3412872C134018914 @default.
• W3412872 hasConceptScore W3412872C2777714996 @default.
• W3412872 hasConceptScore W3412872C2778384902 @default.
• W3412872 hasConceptScore W3412872C2778754761 @default.
• W3412872 hasConceptScore W3412872C2779594886 @default.
• W3412872 hasConceptScore W3412872C2779627488 @default.
• W3412872 hasConceptScore W3412872C2780091579 @default.
• W3412872 hasConceptScore W3412872C2780694816 @default.
• W3412872 hasConceptScore W3412872C2780931953 @default.
• W3412872 hasConceptScore W3412872C526584372 @default.
• W3412872 hasConceptScore W3412872C71924100 @default.
• W3412872 hasConceptScore W3412872C86803240 @default.
• W3412872 hasIssue "5" @default.
• W3412872 hasLocation W34128721 @default.
• W3412872 hasLocation W34128722 @default.
• W3412872 hasOpenAccess W3412872 @default.

• next