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- W341404584 abstract "Abstract The effects of various compounds related to adrenergic function (norepinephrine, epinephrine, isoproterenol, propranolol, phentolamine, theophylline, cyclic 3′,5′ AMP, and hydrocortisone) on tritiated thymidine uptake in phytohemagglutinin (PHA)-stimulated lymphocytes were studied. All compounds tested at 10−4M significantly inhibited tritiated thymidine uptake compared to PHA controls. In pulse exposure experiments with more physiologic concentrations performed at the onset of incubation and at the end of incubation (68–72 hr), norepinephrine stimulated tritiated thymidine uptake (an alpha adrenergic effect). Isoproterenol presented at the onset inhibited thymidine uptake but stimulated at the end of incubation (a beta adrenergic effect). The results, while indicating a complex role of the beta receptor mechanism (cyclic 3′,5′ AMP) in the transformation process, show consistent enhancement by the alpha receptor mechanism, an observation which may relate the sympathetic nervous system to immunologic responsiveness." @default.
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- W341404584 date "1970-12-01" @default.
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- W341404584 title "Lymphocyte blast transformation" @default.
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- W341404584 doi "https://doi.org/10.1016/0008-8749(70)90024-9" @default.
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