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• W341709679 abstract "Research Article1 June 1984free access Expression of cholinesterase gene(s) in human brain tissues: translational evidence for multiple mRNA species. H. Soreq H. Soreq Search for more papers by this author D. Zevin-Sonkin D. Zevin-Sonkin Search for more papers by this author N. Razon N. Razon Search for more papers by this author H. Soreq H. Soreq Search for more papers by this author D. Zevin-Sonkin D. Zevin-Sonkin Search for more papers by this author N. Razon N. Razon Search for more papers by this author Author Information H. Soreq, D. Zevin-Sonkin and N. Razon The EMBO Journal (1984)3:1371-1375https://doi.org/10.1002/j.1460-2075.1984.tb01979.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info To resolve the origin(s) of the molecular heterogeneity of human nervous system cholinesterases (ChEs), we used Xenopus oocytes, which produce biologically active ChE when microinjected with unfractionated brain mRNA. The RNA was prepared from primary gliomas, meningiomas and embryonic brain, each of which expresses ChE activity with distinct substrate specificities and molecular forms. Sucrose gradient fractionation of DMSO-denatured mRNA from these sources revealed three size classes of ChE-inducing mRNAs, sedimenting at approximately 32S, 20S and 9S. The amounts of these different classes of ChE-inducing mRNAs varied between the three tissue sources examined. To distinguish between ChEs produced in oocytes and having different substrate specificities, their activity was determined in the presence of selective inhibitors. Both ‘true’ (acetylcholine hydrolase, EC 3.1.1.7) and ‘pseudo’ (acylcholine acylhydrolase, EC 3.1.1.8) multimeric cholinesterase activities were found in the mRNA-injected oocytes. Moreover, human brain mRNAs inducing ‘true’ and ‘pseudo’ ChE activities had different size distribution, indicating that different mRNAs might be translated into various types of ChEs. These findings imply that the heterogeneity of ChEs in the human nervous system is not limited to the post-translational level, but extends to the level of mRNA. Previous ArticleNext Article Volume 3Issue 61 June 1984In this issue RelatedDetailsLoading ..." @default.
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• W341709679 title "Expression of cholinesterase gene(s) in human brain tissues: translational evidence for multiple mRNA species." @default.
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• W341709679 doi "https://doi.org/10.1002/j.1460-2075.1984.tb01979.x" @default.
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