FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W341725904> ?p ?o ?g. }

• W341725904 endingPage "1489" @default.
• W341725904 startingPage "1481" @default.
• W341725904 abstract "Abstract Acute myeloblastic leukemia (AML) blasts have been shown to produce a variety of cytokines in culture such as interleukin-1 (IL-1), IL-6, granulocyte-, macrophage-, and granulocyte-macrophage colony- stimulating factor (GM-CSF), and tumor necrosis factor-alpha (TNF alpha). Using two sensitive and specific enzyme-linked immunosorbent assays for IL-1 beta and GM-CSF, we document in the present study that the production of the two cytokines by AML blasts in culture is coordinated. First, we observe a striking correlation between the levels of GM-CSF and IL-1 beta released by the cells. Thus, a high production of IL-1 beta is always concordant with a high production of GM-CSF and, conversely, low production of IL-1 beta is concordant with low levels of GM-CSF. Second, neutralization of intrinsic IL-1 using antibodies that are specific for IL-1 alpha and -1 beta suppresses the release of GM-CSF by the cells. Third, neutralization of the endogenous source of IL-1 also results in an abrogation of GM-CSF mRNA. Fourth, the production of both IL-1 beta and GM-CSF is up-regulated by exposing AML blasts to an exogenous source of IL-1, suggesting a positive regulation of autocrine growth factor production. Taken together, our results indicate that GM-CSF production by AML blasts is mediated by endogenously produced IL-1. Both IL-1 beta and -1 alpha are produced by AML blasts, although IL-1 beta appears to be more abundant. Spontaneous colony formation by AML blasts is abrogated by the addition of neutralizing antibodies against IL-1 beta and GM-CSF, whereas each antibody alone has little effect on blast proliferation. Taken together, our results are consistent with the view that the production of IL-1 beta by AML blasts supports autocrine growth in culture, through induction of CSFs or other cytokines that stimulate blast proliferation." @default.
• W341725904 created "2016-06-24" @default.
• W341725904 creator A5001805971 @default.
• W341725904 creator A5031601404 @default.
• W341725904 creator A5040194713 @default.
• W341725904 creator A5040706821 @default.
• W341725904 creator A5072994365 @default.
• W341725904 creator A5076143416 @default.
• W341725904 date "1990-10-15" @default.
• W341725904 modified "2023-10-18" @default.
• W341725904 title "Coordinate secretion of interleukin-1 beta and granulocyte-macrophage colony-stimulating factor by the blast cells of acute myeloblastic leukemia: role of interleukin-1 as an endogenous inducer" @default.
• W341725904 cites W110506942 @default.
• W341725904 cites W1539584528 @default.
• W341725904 cites W1548222831 @default.
• W341725904 cites W1576125847 @default.
• W341725904 cites W1584304412 @default.
• W341725904 cites W1586789350 @default.
• W341725904 cites W1589881672 @default.
• W341725904 cites W1973312385 @default.
• W341725904 cites W1975331230 @default.
• W341725904 cites W1977157092 @default.
• W341725904 cites W1978310945 @default.
• W341725904 cites W2005192972 @default.
• W341725904 cites W2010490053 @default.
• W341725904 cites W2014669590 @default.
• W341725904 cites W2034432392 @default.
• W341725904 cites W2039008259 @default.
• W341725904 cites W2077077811 @default.
• W341725904 cites W2092368843 @default.
• W341725904 cites W2095056719 @default.
• W341725904 cites W2102106426 @default.
• W341725904 cites W2112916314 @default.
• W341725904 cites W2134812217 @default.
• W341725904 cites W2138675970 @default.
• W341725904 cites W2170707126 @default.
• W341725904 cites W2283744922 @default.
• W341725904 cites W2344145125 @default.
• W341725904 cites W2381151699 @default.
• W341725904 cites W2384198704 @default.
• W341725904 cites W2402720811 @default.
• W341725904 cites W2405878472 @default.
• W341725904 cites W2408857414 @default.
• W341725904 cites W2427125280 @default.
• W341725904 cites W244364670 @default.
• W341725904 cites W2473170182 @default.
• W341725904 cites W3112356918 @default.
• W341725904 cites W313794022 @default.
• W341725904 cites W313927096 @default.
• W341725904 cites W47648 @default.
• W341725904 cites W2606859313 @default.
• W341725904 doi "https://doi.org/10.1182/blood.v76.8.1481.1481" @default.
• W341725904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2207323" @default.
• W341725904 hasPublicationYear "1990" @default.
• W341725904 type Work @default.
• W341725904 sameAs 341725904 @default.
• W341725904 citedByCount "71" @default.
• W341725904 countsByYear W3417259042013 @default.
• W341725904 countsByYear W3417259042017 @default.
• W341725904 countsByYear W3417259042019 @default.
• W341725904 countsByYear W3417259042022 @default.
• W341725904 crossrefType "journal-article" @default.
• W341725904 hasAuthorship W341725904A5001805971 @default.
• W341725904 hasAuthorship W341725904A5031601404 @default.
• W341725904 hasAuthorship W341725904A5040194713 @default.
• W341725904 hasAuthorship W341725904A5040706821 @default.
• W341725904 hasAuthorship W341725904A5072994365 @default.
• W341725904 hasAuthorship W341725904A5076143416 @default.
• W341725904 hasBestOaLocation W3417259041 @default.
• W341725904 hasConcept C128240485 @default.
• W341725904 hasConcept C131665280 @default.
• W341725904 hasConcept C17991360 @default.
• W341725904 hasConcept C199360897 @default.
• W341725904 hasConcept C203014093 @default.
• W341725904 hasConcept C2776090121 @default.
• W341725904 hasConcept C2776174256 @default.
• W341725904 hasConcept C2777478134 @default.
• W341725904 hasConcept C2777983669 @default.
• W341725904 hasConcept C2778461978 @default.
• W341725904 hasConcept C2778690821 @default.
• W341725904 hasConcept C2779378344 @default.
• W341725904 hasConcept C41008148 @default.
• W341725904 hasConcept C54355233 @default.
• W341725904 hasConcept C74172505 @default.
• W341725904 hasConcept C79484868 @default.
• W341725904 hasConcept C81885089 @default.
• W341725904 hasConcept C86803240 @default.
• W341725904 hasConcept C8891405 @default.
• W341725904 hasConceptScore W341725904C128240485 @default.
• W341725904 hasConceptScore W341725904C131665280 @default.
• W341725904 hasConceptScore W341725904C17991360 @default.
• W341725904 hasConceptScore W341725904C199360897 @default.
• W341725904 hasConceptScore W341725904C203014093 @default.
• W341725904 hasConceptScore W341725904C2776090121 @default.
• W341725904 hasConceptScore W341725904C2776174256 @default.
• W341725904 hasConceptScore W341725904C2777478134 @default.
• W341725904 hasConceptScore W341725904C2777983669 @default.
• W341725904 hasConceptScore W341725904C2778461978 @default.
• W341725904 hasConceptScore W341725904C2778690821 @default.

• next